Preparation method of femoral middle-end regenerative bone scaffold with porous functional gradient structure

Abstract

The invention relates to a porous functional gradient structure support, in particular to a preparation method of a customizable and degradable 3D printing bone implant. The size is designed according to image data of the middle end of a femur obtained through CT scanning, and a metal mixed material serves as a porous bone support material; a matched protective plate is printed by adopting hydroxyapatite contained in a skeleton and mixed with shell powder and the like as main raw materials, the porous scaffold printed by the invention adopts an annular multifunctional gradient structure, the porosity is gradually reduced from outside to inside, the size of a porous implant can be flexibly arranged according to the skeleton damage condition, and the porous scaffold is suitable for repairing moderate and severe skeleton damage and has a good application prospect. And meanwhile, the material has good buffering and protecting effects on damaged parts of bones, and has the advantages of being degradable, high in biological activity and capable of well promoting bone cell formation.

Description

technical field [0001] The invention relates to the technical field of medical devices, in particular to a customizable, multifunctional gradient, degradable, porous bone scaffold implant. Background technique [0002] Bone damage occurs from time to time in daily life. There are many reasons for bone damage, such as trauma or bone disease. Fractures caused by bone diseases are called pathological fractures. In daily life, such diseases can be prevented by drug treatment. Effect, the main reasons for bone damage in life are generally caused by direct violence and indirect violence, but when the bone is faced with medium and large area defects, the use of autologous bone meal or hydroxyapatite and other materials to fill the treatment is often ineffective and difficult to treat. The cycle is long and the pain brought to the patient is huge. [0003] At present, the clinical methods used for fractures mainly include steel plate fixation, external fixation, etc., but they all ...

AI Technical Summary

Problems solved by technology

[0002] Bone damage occurs from time to time in daily life. There are many reasons for bone damage, such as trauma or bone diseases. Fractures caused by bone diseases are called pathological fractures. Such diseases in daily life can be prevented and controlled by drug treatment Effect, the main cause of bone damage in life is generally caused by direct violence and indirect violence, but when the bone is faced with a large area of ​​defect, the effect of filling with autologous bone powder or hydroxyapatite is often poor, and the treatment is difficult. The cycle is long and the pain caused to the patient is huge

[0003] At present, the clinical methods for fractures mainly include plate fixation and external fixator fixation, etc., but all of them need to be taken out by secondary surgery in the later stage. Although the plate fixation is relatively firm, it is easy to react with body fluids in the human body and has low flexibility. Steel nails cause great damage to bones. The most important thing is that the steel plate needs to be removed through a second operation, which is likely to cause secondary injury to the patient. External fixation is easy to fine-tune and minimally invasive, but wound infection and loose fixation may also occur Thereby damaging the peripheral nerve tissue of the injury. During the treatment process, there are also cases of malunion and nonunion with high rates. Improper treatment often leaves forearm rotation dysfunction.

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