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Bladder cancer immunotherapy biomarker, immune risk model and application of bladder cancer immunotherapy biomarker and immune risk model

A biomarker, immunotherapy technology, applied in biological systems, bioinformatics, medical simulation, etc., can solve problems such as the role is not yet clear, and achieve the effect of improving treatment response

Pending Publication Date: 2022-07-15
WEST CHINA HOSPITAL SICHUAN UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In summary, IGFBP7 may provide potential value for cancer immunotherapy, but the role of IGFBP7 in bladder cancer has not yet been clarified

Method used

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  • Bladder cancer immunotherapy biomarker, immune risk model and application of bladder cancer immunotherapy biomarker and immune risk model
  • Bladder cancer immunotherapy biomarker, immune risk model and application of bladder cancer immunotherapy biomarker and immune risk model
  • Bladder cancer immunotherapy biomarker, immune risk model and application of bladder cancer immunotherapy biomarker and immune risk model

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Embodiment Construction

[0031] In order to make the objectives, technical solutions and advantages of the present invention clearer, the technical solutions of the present invention will be described in detail below. Obviously, the described embodiments are only some, but not all, embodiments of the present invention. Based on the embodiments of the present invention, all other implementations obtained by those of ordinary skill in the art without creative work fall within the protection scope of the present invention.

[0032] experiment procedure

[0033] 1. Data source and preprocessing.

[0034] In the present invention, the mRNA sequencing expression profile and clinical information of bladder cancer patients were downloaded from The cancer Genome Atlas (TCGA) (http: / / cancergenome.nih.gov / ). A cohort of atezolizumab-treated advanced urothelial carcinomas (IMvigor210 cohort) was downloaded from a free database (http: / / research-pub.gene.com / IMvigor210CoreBiologies / ). Five bladder cancer dataset...

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Abstract

The invention provides a bladder cancer immunotherapy biomarker, an immune risk model and application of the bladder cancer immunotherapy biomarker and the immune risk model, relates to the technical field of biology, and proves that the T cell recognition capability and the tumor cell killing capability of a high-expression IGFBP7 group in a bladder cancer tumor immune cycle are relatively low, and the enrichment score of an immunotherapy pathway of the high-expression IGFBP7 group is relatively low. And the expression level of the biomarker IGFBP7 is in negative correlation with the bladder cancer immunotherapy response. The IGFBP7 plays an important role in tumor microenvironment regulation and control and affects immunotherapy response. Therefore, the anti-IGFBP7 treatment is expected to improve the response of bladder cancer immune research treatment, and becomes a good drug target for bladder cancer and immunotherapy combined treatment. Besides, an immune risk model based on the IGFBP7 expression quantity is constructed, the model is verified, and the bladder cancer immune risk model based on the IGFBP7 can well predict prognosis and immunotherapy reaction and help clinicians to better select treatment modes.

Description

technical field [0001] The invention relates to the technical field of biology, in particular to a bladder cancer immunotherapy biomarker, an immune risk model and an application thereof. Background technique [0002] Bladder cancer (BLCA) is one of the most common malignant tumors of the urinary system, and more than 200,000 people die of bladder cancer every year. Treatment strategies for bladder cancer include surgical resection, radiotherapy, chemotherapy, and immunotherapy. Patients with early-stage localized bladder cancer can be cured with surgery. However, the 5-year survival rate for patients with metastatic bladder cancer is low. In recent years, great progress has been made in the immunotherapy and targeted therapy of bladder cancer. Immune checkpoint inhibitors (ICIs) are one of the most commonly used types of immunotherapy and are now widely used in the treatment of various cancers. Studies have reported that immune checkpoint inhibitors are effective in bla...

Claims

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Application Information

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IPC IPC(8): G16H50/20G16H50/30G16H50/50G16B5/00G16B20/50G16B35/00G16B50/00
CPCG16H50/20G16H50/30G16H50/50G16B5/00G16B20/50G16B35/00G16B50/00
Inventor 艾建忠易贤彦翎郑筱男徐航张天燚李晋
Owner WEST CHINA HOSPITAL SICHUAN UNIV
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