Method for establishing periodontitis rat animal model by using lateral pressurizer to assist wire ligation

A technique for establishing a method and an animal model, which is applied in veterinary instruments, veterinary surgery, medical science, etc. It can solve problems such as difficult operation and difficult threading, and achieve the effects of speeding up molding, reducing damage, and expanding the gap between molars

Inactive Publication Date: 2022-07-29
广东药科大学附属第一医院
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, it is difficult to operate, and it is difficult to smoothly pass the silk thread through the small molar gap of SD rats.

Method used

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  • Method for establishing periodontitis rat animal model by using lateral pressurizer to assist wire ligation
  • Method for establishing periodontitis rat animal model by using lateral pressurizer to assist wire ligation
  • Method for establishing periodontitis rat animal model by using lateral pressurizer to assist wire ligation

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Embodiment Construction

[0065] In order to make the objectives, technical solutions and advantages of the present invention clearer, the present invention will be further described in detail below with reference to the accompanying drawings and embodiments. It should be understood that the specific embodiments described herein are only used to explain the present invention, but not to limit the present invention.

[0066] It will be understood that the terms "first", "second" and the like used in this application may be used herein to describe various elements, but these elements are not limited by these terms unless otherwise specified. These terms are only used to distinguish a first element from another element. For example, a first xx script could be referred to as a second xx script, and similarly, a second xx script could be referred to as a first xx script, without departing from the scope of this application.

[0067] The silk ligation modeling method in the traditional modeling method mainl...

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Abstract

The model building method comprises the following steps: step 1, firstly, taking two 25 # and 30 # lateral pressurizers with changed forms; step 2, anesthetizing the rats after anesthesia takes effect; 3, fixing the head of the rat; 4, expanding the molar clearance by using a lateral pressurizer with a changed shape; 5, taking the silk thread and winding the silk thread on a lateral pressurizer; step 6, knotting through silk threads; 7, knotting is conducted on the mesial surface of the first molar of the rat; 8, the stability is determined through a probe, and reinforcement is conducted; step 9, further using a lateral pressurizer to stimulate periodontium of the rat to coat porphyromonas gingivalis lipopolysaccharide; step 10, regularly observing a ligation position and coating porphyromonas gingivalis lipopolysaccharide after operation; 11, euthanasia is killed after observation is conducted for 8 weeks; and step 12, after euthanasia, detecting changes of periodontium of the rat before and after modeling through imaging scanning. The modeling method mainly overcomes the defect that threading is difficult in simple ligation modeling.

Description

technical field [0001] The invention belongs to the technical field of periodontology animal models, in particular to a method for establishing an animal model of periodontitis rats assisted by a lateral presser-assisted silk ligation. Background technique [0002] The prevalence of oral diseases in my country has been high, and periodontal disease is the leading one. Periodontal disease refers to diseases that occur in the supporting tissues of the teeth (periodontal tissue), including gingivitis involving only the periodontal tissue and periodontitis involving the deep periodontal tissue (periodontal ligament, alveolar bone, cementum) Two categories. Periodontal disease can lead to partial, most or even complete loss of teeth in patients, which not only impairs the function of the oral chewing system, but may also seriously affect the overall health. The early diagnosis and prevention of periodontal disease is an extremely important part of periodontal disease treatment....

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61D1/00
CPCA61D1/00
Inventor 周倩冰龚亚楠岳振杰郭贵高范菁娴王玉栋周万兴孙菁菁龚薇
Owner 广东药科大学附属第一医院
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