Bioactive composition for preventing and/or treating Alzheimer disease and application thereof
A bioactive technology for Alzheimer's disease, applied in the field of biomedicine, to reduce the degree of brain aging, improve learning and memory impairment, and reduce the level of oxidative stress in the brain
Pending Publication Date: 2022-08-02
XINXIANG MEDICAL UNIV
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- Abstract
- Description
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Problems solved by technology
[0003] The therapeutic effect of the drugs in the prior ar
Method used
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Experimental program
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Embodiment 1
[0040] 8 parts of melatonin, 210 parts of coenzyme Q10 and 60 parts of lecithin were mixed to obtain a biologically active composition.
Embodiment 2
[0042] 12 parts of melatonin, 200 parts of coenzyme Q10 and 55 parts of lecithin were mixed to obtain a biologically active composition.
Embodiment 3
[0044] 10 parts of melatonin, 190 parts of coenzyme Q10 and 65 parts of lecithin were mixed to obtain a biologically active composition.
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The invention relates to a bioactive composition for preventing and/or treating Alzheimer's disease and application thereof, and belongs to the technical field of biological medicine. The bioactive composition disclosed by the invention is prepared from the following components in parts by mass: 8 to 12 parts of melatonin, 190 to 210 parts of coenzyme Q10 and 55 to 65 parts of lecithin. The three components in the bioactive composition have a synergistic effect, and can play a role in protecting cells and organisms through different action mechanisms. The compatibility of the three components can significantly reduce the brain oxidative stress level of D-gal mice, reduce the tau protein phosphorylation level of the cerebral cortex and the hippocampus of the D-gal mice, reduce the brain aging degree and improve the learning and memory disorders of the mice compared with single use of a certain medicine, and provides a basis for prevention and/or treatment of the Alzheimer's disease. A new thought is provided for the development of medicines for preventing and/or treating the Alzheimer disease.
Description
technical field [0001] The present invention relates to the technical field of biomedicine, in particular to a biologically active composition for preventing and / or treating Alzheimer's disease and its application. Background technique [0002] Alzheimer's Disease (AD) is a neurodegenerative disease with a high incidence in the elderly population. Senile plaques and abnormal intracellular hyperphosphorylation are formed by the deposition of extracellular β-amyloid (Aβ). The main pathological feature is neurofibrillary tangles formed by the aggregation of tau protein, and the clinical manifestations are memory loss, aphasia, dementia, and mobility impairment, which are gradually aggravated with age. The gradual increase of oxidative stress level, excessive production of free radicals, and weakening of free radical scavenging ability with age are considered to be the key mechanisms of AD pathogenesis. [0003] The therapeutic effect of the drugs in the prior art on Alzheimer'...
Claims
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Patent Timeline
Login to view more IPC IPC(8): A61K31/685A61K31/122A61K31/4045A61P25/28
CPCA61K31/4045A61K31/122A61K31/685A61P25/28A61K2300/00
Inventor 王璐王建枝魏迎娟孙振州尹雅玲
Owner XINXIANG MEDICAL UNIV
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