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Egg yolk antibody composition for cat infectious peritonitis as well as preparation method and application of egg yolk antibody composition

A yolk antibody and infectious technology, which is applied in the field of gene recombination and antibody preparation, can solve problems such as difficulty in research and development of feline infectious peritonitis vaccine, achieve the effects of preventing feline infectious peritonitis virus infection and solving the problem of high cost

Active Publication Date: 2022-08-02
安徽中起生物科技有限公司
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Due to the generation of mutations and mixing and cross-infection of the two, it is very difficult to develop a vaccine for cat infectious peritonitis, and there is no effective vaccine so far, and there is no specific drug for the disease. Therefore, the present invention provides a cat infectious peritonitis vaccine. Egg yolk antibody composition and its preparation method and application

Method used

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  • Egg yolk antibody composition for cat infectious peritonitis as well as preparation method and application of egg yolk antibody composition
  • Egg yolk antibody composition for cat infectious peritonitis as well as preparation method and application of egg yolk antibody composition
  • Egg yolk antibody composition for cat infectious peritonitis as well as preparation method and application of egg yolk antibody composition

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Embodiment Construction

[0030] The application will be described in further detail below in conjunction with the accompanying drawings. It is necessary to point out that the following specific embodiments are only used to further illustrate the application, and should not be construed as limiting the protection scope of the application. Those skilled in the art can The above application content makes some non-essential improvements and adjustments to this application.

[0031] 1. Materials

[0032] The methods used in this example are conventional methods known to those skilled in the art unless otherwise specified, and the reagents and other materials used are commercially available products unless otherwise specified.

[0033] 2. Methods

[0034] 1. Preparation of recombinant cat enteric coronavirus S protein and preparation of rFECV-S protein yolk antibody

[0035] (1) Acquisition of the gene sequence of recombinant cat enteric coronavirus S protein:

[0036] Referring to the GENBANK accession nu...

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Abstract

The invention belongs to the technical field of gene recombination and antibody preparation, and particularly discloses a cat infectious peritonitis egg yolk antibody composition as well as a preparation method and application thereof. The composition is obtained by mixing a feline intestinal coronavirus S protein egg yolk antibody, a type I feline infectious peritonitis virus S protein egg yolk antibody and a type II feline infectious peritonitis virus S protein egg yolk antibody according to the mass ratio of (1-2): (1-2): (1-2) under the same titer, and compared with a single antibody, the two antibodies are mixed to form the composition. And the three antibodies are mixed according to other proportions, so that the effect of treating feline infectious peritonitis is good. The traditional Chinese medicine composition not only can neutralize cat intestinal coronavirus infection without clinical symptoms so as to prevent cat infectious peritonitis virus infection, but also can neutralize infection of cat infectious peritonitis type I and type II with clinical symptoms so as to achieve the effect of treating cat infectious peritonitis. And particularly, the compound has a relatively good treatment effect on cross infection of type I and type II cat infectious peritonitis viruses.

Description

technical field [0001] The invention belongs to the technical field of gene recombination and antibody preparation, and in particular relates to a feline infectious peritonitis egg yolk antibody composition and a preparation method and application thereof. Background technique [0002] Immunoglobulin of yolk (IgY) is the corresponding antibody extracted from the egg yolk produced by immunizing egg-laying animals, which can be used for the prevention and treatment of corresponding diseases. The properties of IgY are similar to those of mammalian IgG, and IgY has strong heat resistance, acid resistance, ionic strength and certain resistance to enzymatic degradation. [0003] Prokaryotic expression technology refers to the technology of constructing an expression vector of exogenous target protein gene through cloning technology and introducing it into prokaryotic expression cells such as Escherichia coli and expressing it. Rosetta-gami2 series cells can be correctly modified ...

Claims

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Application Information

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IPC IPC(8): C07K16/10C07K16/02C12N15/50C12N15/70A61K39/42A61P31/16
CPCC07K16/10C07K16/02C07K14/005C12N15/70A61P31/16C07K2317/11C07K2317/76C12N2770/20022C12N2770/20051C12N2800/22A61K2039/507A61K2039/552Y02A50/30
Inventor 符修乐卞传忠
Owner 安徽中起生物科技有限公司
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