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Application of isoliensinine in preparation of medicine for preventing or treating colitis

A technology of isoliensinine and colitis, applied in the field of application of isoliensinine in the preparation of drugs for the prevention or treatment of colitis, to achieve the effect of improving loose stools and intestinal atrophy

Pending Publication Date: 2022-08-05
NANJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, whether isoliensinine (IsoL) has preventive and therapeutic effects on colitis has not been reported yet.

Method used

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  • Application of isoliensinine in preparation of medicine for preventing or treating colitis
  • Application of isoliensinine in preparation of medicine for preventing or treating colitis
  • Application of isoliensinine in preparation of medicine for preventing or treating colitis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] Improvement effect of isoliensinine on diarrhea symptoms in mice with colitis

[0036] like figure 1 As shown, on the 10th day of the experimental cycle, the mice in the control group had loose stools, unformed stools and even diarrhea symptoms. The high-dose and medium-dose IsoL treatments could significantly improve the diarrhea symptoms of DSS-induced mice (p < 0.05), but low Dose IsoL treatment and the 5-ASA group failed to significantly improve the abnormal fecal levels in mice.

Embodiment 2

[0038] Ameliorative effect of isoliensinine on colonic length shortening in mice with colitis

[0039] On the 10th day of the experimental cycle, the dead individuals caused by biting each other were removed, the surviving mice in each group were sacrificed, and the colons were taken, and the length from the cecum to the colon was measured and counted. like Figure 2-8 As shown, compared with the blank group, the colon length of the control mice was significantly shortened (p<0.05), and the colon was enlarged. High-dose and medium-dose IsoL treatment can significantly improve DSS-induced colon shortening in mice (p < 0.05). Among them, the treatment effect of high-dose IsoL is uniformly higher, while the middle-dose IsoL greatly alleviates colon shortening pathological phenomenon. Low-dose IsoL failed to significantly alleviate DSS-induced colon shortening in mice. In addition, the therapeutic effect of 5-ASA at the 50 mg / kg dose was less uniform, with no significant differ...

Embodiment 3

[0041] Improvement effect of isoliensinine on colon lesions in mice with colitis

[0042]After the experimental period, the colons of mice in each group were taken for histopathological analysis. like Figure 9 In the blank group, the structure of each layer of the colon was clear and variable, and no obvious lesions were found; in the control group, the structure of each layer of the colon was discernible, with exfoliated cells in the intestinal lumen, a small amount of necrosis and loss of mucosal epithelial cells, and edema of the submucosa. A large number of inflammatory cells were infiltrated and small blood vessels were dilated; in the high-dose IsoL group, the structure of each layer of the colon was discernible, a small amount of mucosal epithelial cells were necrotic and exfoliated, and a small amount of inflammatory cell infiltration was seen in the submucosa; in the middle-dose IsoL group, the colonic layers were discernible, There were exfoliated cells and inflamm...

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Abstract

The invention discloses an application of isoliensinine in preparation of a medicine for preventing or treating colitis, a colitis mouse model is constructed through induction of dextran sulfate sodium salt, and the scheme is verified to be capable of effectively improving the pathological state of a colitis mouse; the traditional Chinese medicine composition has the effects of inhibiting colon length shortening, relieving diarrhea symptoms, inhibiting colon tissue inflammatory cell infiltration, promoting colon tissue repair and the like, and shows good prevention and treatment effects. The invention provides a new medicine choice for preventing and treating colitis, and can obviously improve the phenomena of loose stool and intestinal atrophy caused by colitis.

Description

technical field [0001] The invention relates to the use of a compound, in particular to the application of isoliensinine in the preparation of a medicament for preventing or treating colitis. Background technique [0002] Colitis (colitis) is a clinically multiple intestinal disease, manifested as diarrhea, mucus and pus and blood in the stool. Among them, ulcerative colitis is a refractory complex inflammatory bowel disease characterized by idiopathic, chronic, recurrent and inflammatory conditions of the gastrointestinal tract [Ouyang Qin. Ulcerative Colitis Clinical Diagnostic guidelines [J]. Journal of Clinical Digestive Diseases, 2007, 19(1): 4-6.]. At present, traditional Chinese medicine has obvious advantages and distinctive characteristics in the treatment of colitis [Wang Xinyue, Wang Jianyun. Key issues and advantageous countermeasures of traditional Chinese medicine treatment of ulcerative colitis [J]. China Journal of Traditional Chinese Medicine, 2012, 27(2): ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/4725A61P1/00A61P29/00
CPCA61K31/4725A61P1/00A61P29/00Y02A50/30
Inventor 胡珀潘扬杨光明曹婧米玉辉郭亮肖婧倪烨雯高铭彤
Owner NANJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE
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