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Application of zingerenone a in the preparation of drugs for preventing and treating colitis

A technology for shogatonone and colitis, which is applied in the application field of shogatonone A in preventing and treating colitis, and achieves the effects of reducing colon atrophy, inhibiting colonic mucosal edema, and enhancing intestinal barrier function.

Active Publication Date: 2022-03-08
GUANGZHOU UNIVERSITY OF CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the efficacy of these drugs has certain limitations

Method used

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  • Application of zingerenone a in the preparation of drugs for preventing and treating colitis
  • Application of zingerenone a in the preparation of drugs for preventing and treating colitis
  • Application of zingerenone a in the preparation of drugs for preventing and treating colitis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] Embodiment 1 Zingerenone A affects the clinical symptoms and colon length and thickness of ulcerative colitis model

[0023] 1. Experimental animals:

[0024] SPF grade, male BALB / c mice (6-8 weeks old, 18-22g), purchased from the Experimental Animal Center of Guangzhou University of Traditional Chinese Medicine, license number: SCXK (Guangdong) 2013-0034, animal certificate number: NO .44007200043643. The animals were kept in the SPF experimental animal room of the Experimental Animal Center of Guangzhou University of Traditional Chinese Medicine. The animal feeding conditions were: temperature (20-25°C), humidity (65-70%), 12h light and dark alternately, and the animals were given standard feed during feeding. and sterile distilled water ad libitum, and new litter every other day.

[0025] 2. Experimental method:

[0026] Male BALB / C mice (6-8 weeks old, 18-22g), after 7 days of adaptive feeding, the animals were randomly divided into: normal control group (Normal ...

Embodiment 2

[0030] Example 2 Effect of zingerenone A on colon histopathology in animal model of ulcerative colitis

[0031] The excavated colon tissue after the experiment of Example 1 was taken for histopathological examination of the colon: the colon tissue was fixed in 4% paraformaldehyde fixative. After soaking for 24 hours, the colon tissues were dehydrated and embedded in wax blocks. The thickness of the slices was 4 μm, and the slices were placed in an automatic stainer for HE staining. After HE staining, the slides were mounted with neutral resin. The morphology and inflammatory infiltration of the tissue were observed under a light microscope. The result is as figure 2 shown.

[0032] Depend on figure 2 It can be seen that the structure and morphology of the colon tissue of animals in the DSS model group changed significantly, a large number of inflammatory cells infiltrated, goblet cell necrosis and loss were serious, goblet cell swelling was obvious, the colonic mucosal ...

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Abstract

The invention discloses the application of zingerenone A in the preparation of drugs for preventing and treating colitis. The research of the present invention shows that zingerenone A can significantly improve clinical symptoms such as loose stools and bloody stools caused by colitis, effectively reduce colon atrophy, reduce colon thickness, enhance intestinal barrier function, and inhibit colonic mucosal edema without obvious side effects. Zingerenone A has a significant preventive effect on colitis and can be used in the prevention and treatment of colitis. The invention not only provides a new application of zingerenone A, but also provides a new therapeutic drug and a therapeutic approach for the treatment of colitis.

Description

technical field [0001] The invention belongs to the technical field of biomedicine. More specifically, it relates to the application of zingerenone A in the prevention and treatment of colitis. Background technique [0002] Colitis is one of the clinically frequent intestinal diseases. The main clinical manifestations are diarrhea, abdominal pain, mucus stool and pus and blood stool, tenesmus, and even constipation, and inability to pass stool within several days; it is often accompanied by weight loss and fatigue. Recurrent. Among them, the incidence of ulcerative colitis (Ulcerative colitis, UC) is gradually increasing, and the course of the disease is lengthy, and the mortality rate of colorectal cancer (CRC) induced by it has surpassed liver cancer and gastric cancer, so it is more and more popular among people. more attention. [0003] At present, the drugs for the treatment of colitis mainly include: glucocorticoids, 5-aminosalicylic acids and immunosuppressants. H...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/12A61P29/00A61P1/00A61P1/04
CPCA61K31/12A61P29/00A61P1/00A61P1/04
Inventor 梁健肖红钰
Owner GUANGZHOU UNIVERSITY OF CHINESE MEDICINE
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