Chinese medicament for treating atrophic gastritis and preparation method thereof

A technology for atrophic gastritis and drugs, applied in the field of drugs for the treatment of atrophic gastritis, can solve the same problems and achieve the effects of easy acceptance, simple and scientific process, and comprehensive indications

Inactive Publication Date: 2012-11-14
FOURTH MILITARY MEDICAL UNIVERSITY
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Chronic atrophic gastritis belongs to the category of "epigastric pain" and "f

Method used

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  • Chinese medicament for treating atrophic gastritis and preparation method thereof
  • Chinese medicament for treating atrophic gastritis and preparation method thereof
  • Chinese medicament for treating atrophic gastritis and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Example Embodiment

[0022] Animal experiment example 1: The effect of p-xylene-induced ear swelling in mice

[0023] The effect of the capsule of the present invention on the ear swelling of mice caused by xylene was observed. Test powder, batch number: 100101; xylene, domestic analytical grade. The positive control drug selected Yangwei Granule, batch number: 090403, Chia Tai Qingchunbao Pharmaceutical Co., Ltd. The experimental animals were selected from Kunming mice, provided by the Experimental Animal Center of the Fourth Military Medical University.

[0024] Fifty mice were randomly divided into 5 groups, 10 mice in each group, weighing 20±2.5g, and the corresponding dose was given once a day for 6 consecutive days. One hour after the last dose, each mouse was given 0.05ml xylene in the right ear Inflammation, the left ear was used as a control, and the patients were killed for 15 minutes after the inflammation. Both ears were cut off, and round ear pieces were punched on the same part with a 6...

Example Embodiment

[0028] Animal experiment example 2: Effect on pain in mice

[0029] (1) Hot plate method: 50 mice were randomly divided into 5 groups, 10 mice in each group, and the dosage was the same as above. 1h after the last administration, put the mouse into a hot beaker (constant temperature water bath 55℃±1℃); and immediately count the time (s) from the time the mouse is put into the beaker to lick the hindfoot as the The pain threshold of the mouse and the increase rate of the pain threshold are calculated. The calculation formula is: [(average pain threshold after medication-average pain threshold of untreated group) / average pain threshold of untreated group]×100%. The results showed that the test drugs 0.80g / kg and 0.40g / kg had significant analgesic effects (P<0.01).

[0030] Table 2 Effects on pain in mice (n=10; )

[0031]

[0032] Note: * P<0.01 compared with the model group.

[0033] (2) Writhing method: each mouse ip 0.5% acetic acid solution (20ml / kg) 30 minutes after the last adm...

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Abstract

The invention provides a Chinese medicament for treating atrophic gastritis and a preparation method thereof, and belongs to the technical field of Chinese medicament preparation. The Chinese medicament is prepared from natural Chinese herbal medicines as raw material prescription, and is characterized by comprising the following natural Chinese herbal medicines in parts by weight: 20 to 40 parts of astragalus mongholicus, 15 to 30 parts of raw rehmannia root, 10 to 20 parts of dwarf lilyturf tuber, 20 to 40 parts of white peony root, 10 to 20 parts of Chinese angelica, 8 to 16 parts of curcuma zedoary, 8 to 16 parts of corydalis tuber, and 3 to 6 parts of goldthread. Studies prove that the Chinese medicament has the functions of tonifying qi and nourishing yin, activating blood circulation to relieve pains, and treating chronic atrophic gastritis. The medicament has certain effects in improving symptoms, strengthening appetite, promoting digestion, relieving pains and the like, has no remarkable adverse response and high safety, is especially suitable for treating middle-aged and aged patients with chronic atrophic gastritis, and is rich in raw material sources and low in production cost, so that the economic burden of the patient can be greatly reduced by taking the medicament.

Description

Technical field [0001] The invention belongs to a medicine for treating atrophic gastritis, in particular to a traditional Chinese medicine preparation composed of Chinese herbal medicine extracts. Background technique [0002] Chronic atrophic gastritis, also known as atrophic gastritis, is one of the common diseases of the digestive system. It refers to the pathological changes in which the mucosal glands atrophy or even disappear after repeated damage to the surface of the gastric mucosa, and the muscularis mucosa often thickens. Due to the atrophy or disappearance of the glands, the gastric mucosa is thinned to varying degrees, often accompanied by intestinal metaplasia, inflammatory reactions and atypical hyperplasia; arteriosclerosis, insufficient gastric blood flow, addiction to tobacco, alcohol and tea, etc. are easily damaged The disease is caused by the barrier function of the gastric mucosa. The clinical manifestations of this disease are loss of appetite, nausea...

Claims

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Application Information

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IPC IPC(8): A61K36/9066A61K9/16A61K9/20A61K9/48A61P1/04
Inventor 石小鹏栗艳缪珊张伟吴振宇吴寅冯娟文爱东
Owner FOURTH MILITARY MEDICAL UNIVERSITY
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