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Application of 2-methoxyestradiol in preparation of medicine for treating psoriasis

A technology of methoxyestradiol and psoriasis, applied in the field of psoriasis treatment drugs, can solve problems such as affecting the physical and mental health of patients, unknown etiology and pathogenesis, lack of treatment methods, etc.

Pending Publication Date: 2022-08-09
ZHONGSHAN HOSPITAL FUDAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

So far, the etiology and pathogenesis of the disease are unknown, and there is a lack of effective treatment methods. The recurrent course of the disease seriously affects the physical and mental health of patients.

Method used

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  • Application of 2-methoxyestradiol in preparation of medicine for treating psoriasis
  • Application of 2-methoxyestradiol in preparation of medicine for treating psoriasis
  • Application of 2-methoxyestradiol in preparation of medicine for treating psoriasis

Examples

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Effect test

Embodiment 1

[0054] (1) Preparation of external ointment for the treatment of psoriasis

[0055] The preparation method of the external ointment for treating psoriasis comprises the following steps:

[0056] First, add vaseline and lanolin in a ratio of 9:1 by weight to a centrifuge tube, then put it in a water bath at 50°C and heat it. After the paste-like solid is melted, mix well and leave it at room temperature until it returns to an ointment. , as a base for backup;

[0057] Dissolve the calculated and weighed 2-methoxyestradiol powder in dimethyl sulfoxide, and stir until dissolved to obtain a 2-methoxyestradiol solution;

[0058] Put the pre-prepared ointment base into a water bath and melt at 50°C, put the 2-methoxyestradiol solution into the melted base and stir well;

[0059] Finally, take the solution out of the water bath and place it at room temperature, and while stirring, wait for the solution to become an ointment-like semi-solid to obtain an external ointment for the tre...

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Abstract

The invention relates to an application of 2-methoxyestradiol in preparation of a medicine for treating psoriasis. The research finds that 2-methoxyestradiol has the characteristics of anti-proliferation, anti-inflammation and anti-angiogenesis, and accords with the pathogenesis link of psoriasis, so that the 2-methoxyestradiol is prepared into an external preparation, especially an ointment, and can be externally applied to treat psoriasis. An animal model and a cell model prove that the 2-ME has an exact curative effect on skin lesion of a psoriasis model mouse; in a psoriasis cell model, the cell proliferation and angiogenesis inhibition and anti-inflammatory effects of 2-ME are proved. Therefore, the invention proves that the 2-methoxyestradiol has the function of treating psoriasis, not only that, the 2-methoxyestradiol for external use is good in tolerance, safe and free of obvious toxic and side effects, but also the operation of preparing the ointment for external use by using the 2-ME is easier.

Description

technical field [0001] The invention belongs to the technical field of psoriasis treatment medicines, in particular to the application of 2-methoxyestradiol in the preparation of medicines for the treatment of psoriasis. Background technique [0002] Psoriasis is one of the most common chronic relapsing inflammatory skin diseases with a global incidence of 0.1-2%. Psoriasis has three pathogenic links: hyperproliferation of keratinocytes, dermal angiogenesis, and immune inflammation. So far, the etiology and pathogenesis of the disease are unknown, and effective treatment methods are lacking. The recurrent course of the disease seriously affects the physical and mental health of patients. Therefore, it is urgent to find drugs that can specifically block the onset of psoriasis and have less toxic and side effects, in order to effectively control the disease and improve the quality of life of patients. SUMMARY OF THE INVENTION [0003] In order to find a drug that can speci...

Claims

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Application Information

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IPC IPC(8): A61K31/565A61K9/06A61K47/06A61K47/44A61P17/06
CPCA61K31/565A61K9/0014A61K9/06A61K47/06A61K47/44A61P17/06Y02A50/30
Inventor 朱鹭冰唐嘉萱刘超凡刘世颖
Owner ZHONGSHAN HOSPITAL FUDAN UNIV
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