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Novel antitumor compound philinopside B from striped pseudo-manatee

A technology of anti-tumor drugs and compounds, applied in the field of medicine

Inactive Publication Date: 2004-05-26
SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

So far, there are only reports about the anti-tumor compound Philinopside A extracted from the striped manatee Philinopsislineolate

Method used

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  • Novel antitumor compound philinopside B from striped pseudo-manatee
  • Novel antitumor compound philinopside B from striped pseudo-manatee

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0064] Further describe the separation and preparation of Philinopside B by the examples below

[0065] Select 3400 grams (dry product) of the striped manatee grown in the South China Sea, soak it with 10 liters of 70% ethanol for 72 hours, repeat the extraction three times, combine the extracts, and recover under reduced pressure to obtain about 400 grams of extract. The extract was suspended in 2 liters of 30% ethanol, extracted 4 times with 2 liters of ether, and the alcoholic solution in the lower layer was recovered under reduced pressure to obtain 240 grams of alcoholic extract. Redissolved in 5 liters of distilled water, passed through a macroporous resin column, and eluted successively with 10 liters of distilled water, 5 liters of 50% ethanol and 5 liters of 95% ethanol until colorless. Collect the 95% ethanol eluate, recover the solvent under reduced pressure to dryness, and obtain 14 grams of total saponins. The total saponins were subjected to silica gel column ch...

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Abstract

A kind of antiknub compound Philinopside B whose molecular formula is C55H84O28S2Nas separated from stripe like cowfish is disclosed in the invention, which is belong to medicine technology field. After modern multi-spectrum and in particular many advanced 2D NMR synthesis analysis, chemistry structure and tridimensional structure of the compound are confirmed as a new compound. The antiknub test is vitro indicates that the compound has obvious restraint effect of A-549 lung cancer etc. l10 kinds of human knub cell strain. The invention provides forerunner compound for new antiknub medicine preparation, and has important value for exploitation and usage of Chinese ocean biology resource as medicine.

Description

technical field [0001] The invention relates to the technical field of medicine, and is a new anti-tumor compound Philinopside B isolated from the marine animal striped manatee. Background technique [0002] Striped manatee Philinopsis lineolate, collected from the sea area of ​​Zhanjiang, Guangdong, is used in the folk for treating stomach problems. The manatee has a red body wall, about 5-10cm long, and has spinous processes on the back. It is a marine echinoderm (Phylum Echinodermata). The main secondary metabolites of echinoderms are saponins, which are the main material basis of their chemical defense and have various biological activities such as antifungal, anticoagulant, immune regulation, cytotoxicity and antiviral. In the in vitro cytotoxic activity screening, it was found that the methanol extract of Pseudomonas striata had strong cytotoxic activity on human promyelocytes HL-60, IC 50 =14μg / ml, and can induce the deformation of Pyricularia oryzae mycelium, the m...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/585A61P35/00C07J71/00
Inventor 易杨华许强芝李玲吴久鸿
Owner SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY