Surface tension driving liquid flow chiplized high-density micro-array liquid transferring equipment

A technology of surface tension and transfer device, which is used in material inspection products, biological testing, etc., can solve the problems of a lot of time for cleaning and drying the needle tip, the uniformity of the sample points that are easily damaged by the needle tip, and the small number of sampling needles. Low cost, low equipment cost, good uniformity

Inactive Publication Date: 2005-04-06
XIAMEN UNIV
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Problems solved by technology

The main disadvantage of this method is that the expensive needle point is easy to damage and the uniformity of sample points is relatively poor (Chinese patent CN1302904), although people have designed many kinds of sampling needles (U.S. Patent Augenlicht4,981,783; Drmanac et al., U.S. Patent 5,525,464; Roach, U.S. Patent 5,770,151; Brown et al., U.S. Patent 5,807,522; Chinese Patent CN1302904) to make up for these shortcomings, utilize this method to make hig

Method used

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  • Surface tension driving liquid flow chiplized high-density micro-array liquid transferring equipment
  • Surface tension driving liquid flow chiplized high-density micro-array liquid transferring equipment

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Embodiment Construction

[0024] Such as figure 1 As shown, a metal sheet is selected as the sheet-shaped carrier 1 of the present invention, and its size is selected as 100 mm in length, 40 mm in width, and 1 mm in thickness. A circular liquid storage pool 2 is set on the upper surface of the glass sheet by photolithography technology, its radius is 0.3 mm, and its height is 0.8 mm; a cylindrical liquid transfer head 3 is set beside the liquid storage pool 2, and the radius of the liquid transfer head 3 is 0.05 mm. mm. The liquid storage pool 2 and the liquid transfer head 3 are designed in a paired array, and the distance between adjacent liquid storage pools can be set to 0.4 mm. A long and narrow closed microchannel 4 is connected between the liquid reservoir 2 and the upper port of the liquid transfer head 3 .

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Abstract

The invention relates to a chip high density micro-array liquid transferring apparatus comprising a sheet shape carrier with micro-array liquid transferring combination, the combination includes liquid storing portion, liquid transferring head and micro-channel, the micro-channel is linked between the liquid storing portion and the liquid transferring head. By using chip high density micro-array liquid transferring structure, and since the micro-liquid flow of the microscale liquid transferring for the whole apparatus only depends on the acting of surface tension, the manufacturing cost is lower, and the reproducibility of the transferring volume is good.

Description

technical field [0001] The invention relates to a chip-based high-density microarrayer technique on chip device. The device integrates thousands of groups of liquid transfer combinations on a chip, and is called a microarrayer technique on chip. Transfer chip (microarrayer chip), which is a high-density array with precise volume control, high-efficiency and low-cost ultra-micro liquid transfer device. Background technique [0002] Biological / chemical microarray (Biological / chemical microarray) refers to the use of industrial technologies such as microelectronics and micromechanics to immobilize biological or chemical molecules in a certain position on solid-phase carriers such as glass, silicon wafers, and plastics, and to make them used in The product of biological / chemical analysis, its target can be gene, protein or cell tissue, etc. The currently developed biological / chemical microarray products include Genechip (DNAchip or Microarray), protein chip (protein chip), micr...

Claims

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Application Information

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IPC IPC(8): C12Q1/68G01N33/50G01N33/53G01N33/68
Inventor 田昭武林华水周勇亮
Owner XIAMEN UNIV
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