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Medicine for acute ischemic apoplexy and its preparing method

A technique for ischemic stroke and acute phase, applied in drug combinations, pharmaceutical formulas, medical preparations containing active ingredients, etc., can solve problems such as bleeding and inaccurate drug efficacy, and achieve reduction of blood fibrinogen concentration, Reducing the size of cerebral infarction and improving the effect of hemiplegia syndrome

Inactive Publication Date: 2005-05-04
张晴龙
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, the western medicines used clinically for the acute stage of ischemic stroke include streptokinase and Agkistrodon halys antithrombotic enzyme, etc., but there are side effects that easily cause bleeding, etc. Traditional Chinese medicine injections include Xinnaojing and Qingkailing injections, etc. Although It has a certain curative effect on the treatment of ischemic stroke, but all of them have certain indications or limitations, and the curative effect of some drugs is not exact

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] 1. Take 200g of Danshen decoction pieces, add 10 times the amount of water, heat and decoct 3 times, 1.5 hours each time, combine 3 times of water extracts, concentrate under reduced pressure to a relative density of 1.10-1.15 (50°C), add 5% gelatin Aqueous solution, stirring continuously, until the supernatant does not produce precipitation, let it stand for 30 minutes, add ethanol until the alcohol content reaches 75%, stir evenly, refrigerate for 24 hours, filter, recover ethanol under reduced pressure and concentrate to a relative density of 1.30 ( 60°C), vacuum-dried to obtain Danshen extract.

[0018] 2. Take 180g of Radix Paeoniae Rubra, crush it into a coarse powder, add 6 times the amount of 70% ethanol, heat and reflux twice, each time for 2 hours, combine the two alcohol extracts, recover the ethanol under reduced pressure and concentrate to a relative density of 1.10-1.15 (50°C), refrigerated for 72 hours, filtered, the filtrate was extracted 4 times with an...

Embodiment 2

[0022] 1. Take 220g of Danshen decoction pieces, add 13 times the amount of water, heat and decoct twice for 2.5 hours each time, combine the two water extracts, concentrate under reduced pressure to a relative density of 1.10-1.15 (50°C), add 5% gelatin Aqueous solution, stirring continuously, until the supernatant does not produce precipitation, stand still for 60 minutes, add ethanol until the alcohol content reaches 80%, stir evenly, refrigerate for 48 hours, filter, recover ethanol under reduced pressure and concentrate to a relative density of 1.35 ( 60°C), vacuum-dried to obtain Danshen extract.

[0023] 2. Take 200g of Radix Paeoniae Rubra, crush it into a coarse powder, add 8 times the amount of 80% ethanol, heat and reflux 3 times, each time for 2 hours, combine the ethanol extract, recover the ethanol under reduced pressure and concentrate to a relative density of 1.10-1.15 (50 ℃), refrigerated for 28 hours, filtered, and the filtrate was extracted 5 times with an e...

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PUM

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Abstract

The invention discloses a medicine for treating the acute stage of ischemic apoplexy. It takes salvia miltiorrhiza, red peony root and calamus as raw materials, and is extracted to make an injection according to the different characteristics of each traditional Chinese medicine. The medicine of the invention is used for the acute stage treatment of ischemic apoplexy, and has the functions of promoting blood circulation, removing blood stasis, resolving phlegm and dredging collaterals. The results of clinical trials show that the medicine of the present invention has a good therapeutic effect on cerebral embolism, can significantly increase the local blood flow of the brain, improve the hemiplegia syndrome caused by cerebral embolism, reduce the infarct size in the brain, and reduce cerebral edema and nerve cell secondary Sexual damage; significantly inhibit platelet aggregation and thrombus formation; effectively prolong blood coagulation time; have obvious protective effect on brain neuron damage caused by hypoxia and reoxygenation.

Description

Technical field [0001] The invention relates to a medicine for treating ischemic stroke, in particular to a Chinese patent medicine prepared from Chinese herbal medicine, and also relates to a preparation method of the medicine. Background technique [0002] Ischemic stroke (equivalent to ischemic cerebrovascular disease in western medicine) is a common and frequently-occurring disease that seriously endangers human health, and the disability rate is as high as more than 70%. In terms of treatment, with the continuous development of modern medicine, the level of diagnosis and rescue treatment of stroke is also increasing day by day, which greatly reduces the mortality rate in the acute stage and guarantees the life of patients. However, about 3 / 4 of the patients in clinical Incapacitated, the disability rate is as high as 75%, of which the severe disability rate accounts for 40%. Therefore, it is an important topic for medical researchers to develop drugs that can effective...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61P9/10
Inventor 张晴龙
Owner 张晴龙
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