Coronary artery skeleton medicinal coating for preventing restenosis of blood vessel

Abstract

A coated medicine layer on the scaffold in arteria coronaria for preventing angiostenosis is prepared through dissolving the aliphatic polylactone and its copolymer is solvent, adding taxusol, stirring while dissolving, filtering, coating on the scaffold, evaporating the solvent, removing the solvent for 48 hr under vacuum, and disinfecting by epoxy ethane.

Description

technical field

[0001] The invention relates to a coronary stent drug coating for preventing restenosis of blood vessels, which uses paclitaxel as anti-restenosis drug and biodegradable aliphatic polylactone as drug carrier. Background technique

[0002] The popularization and application of coronary artery balloon angioplasty once brought good news to many patients with coronary heart disease, but the biggest defect of this treatment - restenosis of blood vessels has largely limited its curative effect. At present, the mechanism of vascular restenosis has been elucidated, indicating that the occurrence of vascular restenosis is related to multiple factors such as elastic recoil and thrombus formation in the early stage after surgery, smooth muscle migration and hyperplasia in the middle stage, and vascular remodeling in the late stage. To prevent the occurrence of restenosis, a lot of research has been carried out over the years, and treatment methods such as intravascular ...