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Coronary artery skeleton medicinal coating for preventing restenosis of blood vessel

A technology of drug coating and inner stent, which can be used in drug combination, drug delivery, cardiovascular system diseases, etc., and can solve the problems of accelerated diffusion and increased drug release.

Inactive Publication Date: 2003-07-16
INST OF CHEM CHINESE ACAD OF SCI +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

When a biodegradable polymer material is used as a drug carrier, although the release rate of the drug from the carrier will also slow down with the decrease of the drug content, due to the gradual degradation of the drug carrier, the structure of the carrier becomes loose, making the The speed of dissolution and diffusion of drug molecules from the carrier to the body is accelerated, and the amount of drug release is increased

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Example 1: After 0.1 g of poly(lactide-glycolide) random copolymer (PLGA, lactide / glycolide=50 / 50 (mol / mol)) was dissolved in 5 ml of chloroform, 2 mg Paclitaxel, stirred, dissolved evenly and filtered, sprayed onto the surface of 316L stainless steel stent, volatilized the solvent in the air, then repeated spraying once, volatilized the solvent in the air and then desolvated at room temperature under vacuum for 48 hours, paclitaxel in the stent The content is 50μg. After being sterilized by ethylene oxide and implanted into the coronary artery of the dog, no thrombus was found two weeks later.

Embodiment 2

[0027] Example 2: 0.1 g poly(lactide-glycolide-caprolactone) random copolymer (PGLC, lactide / glycolide / caprolactone=45 / 45 / 10 (mol / mol)) After dissolving in 3ml of dichloromethane, add 2mg of paclitaxel, stir, dissolve evenly and filter, dip-coat on the surface of 316L stainless steel stent, volatilize the solvent in the air, and then desolventize at room temperature under vacuum for 48 hours, the The paclitaxel content was 85 μg. After sterilized by ethylene oxide, the canine coronary artery was implanted, and there was no thrombus formation after three weeks.

Embodiment 3

[0028] Example 3: 0.1 g poly(lactide-glycolide-caprolactone) random copolymer (PGLC, lactide / glycolide / caprolactone=45 / 45 / 10 (mol / mol)) After dissolving in 3ml of dichloromethane, add 2mg of paclitaxel, stir, dissolve evenly and filter, dip-coat on the surface of 316L stainless steel stent, volatilize the solvent in the air, then repeat the dip-coating again, volatilize the solvent in the air and then apply it in vacuum The solvent was desolvated at room temperature for 48 hours under conditions, and the content of paclitaxel in the scaffold was 250 μg. After being sterilized by ethylene oxide and implanted into the coronary artery of the dog, no thrombus was found after two months.

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PUM

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Abstract

A coated medicine layer on the scaffold in arteria coronaria for preventing angiostenosis is prepared through dissolving the aliphatic polylactone and its copolymer is solvent, adding taxusol, stirring while dissolving, filtering, coating on the scaffold, evaporating the solvent, removing the solvent for 48 hr under vacuum, and disinfecting by epoxy ethane.

Description

technical field [0001] The invention relates to a coronary stent drug coating for preventing restenosis of blood vessels, which uses paclitaxel as anti-restenosis drug and biodegradable aliphatic polylactone as drug carrier. Background technique [0002] The popularization and application of coronary artery balloon angioplasty once brought good news to many patients with coronary heart disease, but the biggest defect of this treatment - restenosis of blood vessels has largely limited its curative effect. At present, the mechanism of vascular restenosis has been elucidated, indicating that the occurrence of vascular restenosis is related to multiple factors such as elastic recoil and thrombus formation in the early stage after surgery, smooth muscle migration and hyperplasia in the middle stage, and vascular remodeling in the late stage. To prevent the occurrence of restenosis, a lot of research has been carried out over the years, and treatment methods such as intravascular ...

Claims

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Application Information

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IPC IPC(8): A61K9/00A61K31/337A61K47/34A61L31/14A61L33/00A61P9/00
Inventor 王身国盖鲁粤蔡晴陈练贝建中杜洛山
Owner INST OF CHEM CHINESE ACAD OF SCI
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