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A hollow tubular biodegradable drug delivery system and its preparation method

A biodegradable drug delivery system technology, applied in the field of hollow tubular biodegradable drug delivery system and its preparation, can solve the problems of "explosive release of drugs, difficulty in achieving constant drug release, etc., and achieve a wide range of clinical applications" Effect

Active Publication Date: 2019-11-08
杨立群
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Its disadvantage is that the stent itself does not contain drugs, and its function is limited to the mechanical support of the drug film layer
The disadvantage is that the release rate of the drug is only regulated by the degradation rate of the outer release tube, and it is difficult to achieve a constant release rate of the drug; in addition, the drug inside the drug core is difficult to contact with body fluids and accumulates in the carrier material. Deformation or performance collapse, prone to drug "burst release" effect

Method used

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  • A hollow tubular biodegradable drug delivery system and its preparation method
  • A hollow tubular biodegradable drug delivery system and its preparation method
  • A hollow tubular biodegradable drug delivery system and its preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] Poly(2,2-dimethyl-trimethylene carbonate) was prepared by ring-opening polymerization of 2,2-dimethyl-trimethylene carbonate, a derivative of trimethylene carbonate. Mix poly(2,2-dimethyl-trimethylene carbonate) and gestodene in a mass ratio of 3:1, and add 2-methyl-4-(2 - Methylpropyl) phenylacetic acid, after mixing evenly, extruding with a miniature single-screw extruder to obtain a hollow tubular biodegradable drug delivery system with an outer diameter of 1.0-5.0 mm and a wall thickness of 0.2-2 mm.

Embodiment 2

[0039] Mix polycaprolactone and gestodene at a mass ratio of 2.5:1, add acetaminophen accounting for 5% of the total mass of the mixture, and mix evenly. The hollow tubular drug delivery system prepared in Example 1 is used as a mold core and placed in the middle of the mixed materials, and put together into a mold for compression molding to obtain a double-layer hollow tubular drug delivery system. Among them, the hollow tubular drug delivery system prepared in Example 1 is used as the inner layer, the outer layer of the hollow tubular biodegradable drug delivery system (outer diameter 1.4-9.0 mm, wall thickness 0.2-2 mm) formed by molding and the hollow tubular biodegradable drug delivery system The inner layer of the biodegradable drug delivery system (with an outer diameter of 1.0-5.0 mm and a wall thickness of 0.2-2 mm) is firmly combined to form a double-layer hollow tubular biodegradable drug delivery system.

Embodiment 3

[0041] Mix poly(trimethylene carbonate-hydroxycaprolactone) and paclitaxel uniformly at a mass ratio of 4:1, and then inject with an injection molding machine to obtain a hollow tubular drug delivery system with an outer diameter of 0.2-3.0 mm and a wall thickness of 0.05-1.0 mm the inner layer. Mix poly(p-dioxanone-lactide) and paclitaxel at a mass ratio of 5:1, add 2-(acetoxy)benzoic acid accounting for 3% of the total mass of the mixture, and mix well. Place the inner layer of the obtained hollow tubular drug delivery system as a mold core in the middle of the mixed materials, put them together into the mold for compression molding, and form the outer layer of the hollow tubular biodegradable drug delivery system (outer diameter: 0.3 to 5.0 mm) by molding. , wall thickness 0.05-1.0mm) and the inner layer of the hollow tubular biodegradable drug delivery system (outer diameter 0.2-3.0mm, wall thickness 0.05-1.0mm) are firmly combined to form a double-layer hollow tubular bio...

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Abstract

The invention relates to the field of chemical and medical biological materials and biomedicine, in particular to a hollow tubular biodegradable medication system and a preparation method thereof. Medicines are directly loaded between the inner wall and the outer wall of a biodegradable tube by co-melting extrusion, injection molding and mould pressing technologies or a one-step polymerization molding method. The hollow tubular biodegradable medication system is simple in technology and easy to operate, medicine loading capacity of the medication system can be realized by means of changing parameters such as length and wall thickness of the tube, a medicine 'burst release' effect generated by degradation of a polymer tubular carrier can be eliminated effectively, and degradation rate of biodegradable polymers of inner and outer layers can be controlled. The inside and outside of the system can be in contact with body fluid fully, and constant medicine release rate is realized by means of regulating and controlling the degradation rate of the inner and outer walls of the tube. The system has good biodegradability, good biological compatibility and constant medicine releasing speed, and has a high application prospect in the fields of tissue engineering and medicine sustained release.

Description

technical field [0001] The invention relates to the fields of chemistry, medical biomaterials and biomedicine, in particular to a hollow tubular biodegradable drug delivery system and a preparation method thereof. Background technique [0002] Controlled drug release is beneficial to improve the efficacy of drugs, reduce side effects, and reduce the pain of repeated drug use for patients. For a long time, drug carriers based on polymer materials have been the most active research system in the field of controlled drug release. The release system using polymers as drug carriers first appeared in the 1980s. Segal et al. used silicone rubber as a carrier material to pack progesterone in silicone rubber microcapsules for family planning research. The results of the study showed that the drug was released slowly over a long period of time, and the therapeutic effect was satisfactory. But the problem is that it is found that organosilicon materials can induce cancer after long-t...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61M31/00A61L31/06A61L31/14A61L31/16
Inventor 杨立群李建新
Owner 杨立群
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