Polylactic acid/amino acid ester blend and its preparing method

A technology of amino acid ester and polylactic acid, which is applied in the field of polylactic acid/amino acid ester blend and its preparation, can solve the problems of high cost, complicated process, staying in polylactic acid crystallinity, hydrophilicity and degradation performance, etc.

Inactive Publication Date: 2006-02-01
SICHUAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] However, the above studies all use chemical modification method, the process is complicated and the cost is high
Some people in China use polyethylene glycol, polyvinyl alcohol and polylactic acid to blend, but these studies only stay in the crystallinity, hydrophilicity and degradation performance of polylactic acid.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0021] 1. DL-polylactic acid (PLA) 52g, L-glycine ethyl ester 26g, solvent methylene chloride 200g, add in the reaction bottle with stirrer, thermometer and reflux condenser, stir until completely dissolved, then gradually heat to 40 ℃, after reacting for 90 minutes, evaporate the solvent to dryness, reduce the pressure to 0.01Mpa, and sublime the residual solvent to obtain a DL-polylactic acid / L-glycine ethyl ester blend.

[0022] 2. Dissolve 51g of L-polylactic acid and 20g of L-lysine benzyl ester in 100g of tetrahydrofuran, 100g of tetrahydrofuran, and 100g of dichloromethane in a mixed solvent, and put them into a reaction flask with a stirrer, a thermometer and a reflux condenser , stirring to fully dissolve, the reaction temperature to 60 ° C, after 80 minutes of heat preservation, the solvent was evaporated, and the solvent was removed at a vacuum degree of 0.05Mpa. The L-polylactic acid / L-lysine benzyl ester blend was obtained.

[0023] 3. In the same equipment as in...

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PUM

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Abstract

The present invention discloses a kind of polylactic acid / amino acid ester blend and its preparation process. The blend is polylactic acid modified through solution blending process, in which polylactic acid in 50-95 portions and amino acid or amino acid ester in 5-50 portions are dissolved in solvent in 150-300 portions, mixed homogeneously and reacted at 30-150 deg.c for 30-90 min; most of solvent is then eliminated through heating; and the rest of solvent is eliminated via decompression to 0.09-0.8 MPa to obtain polylactic acid / amino acid ester blend. The blend material has excellent biocompatibility and may be used as tissue rack material.

Description

1. Technical field [0001] The invention relates to a polylactic acid / amino acid ester blend and a preparation method thereof, belonging to the field of polymer blend modification. 2. Background technology [0002] Polylactic acid (PLA) has degradability and good biocompatibility, and has been widely used in drug controlled release, surgical sutures, fracture internal fixation materials, etc., and has become a very important high polymer in biomedical materials. material. At the same time, it is also the main matrix material in tissue engineering, and has been made into various forms of scaffolds for the body. However, the biocompatibility is not ideal. Due to the lack of good hydrophilicity, it is not conducive to cell adhesion, proliferation and differentiation; in the biological environment, the inflammatory effect cannot be completely ruled out. This is because the synthetic matrix material lacks the molecular recognition sequence unique to the natural matrix, and the c...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08L67/04C08K5/205
Inventor 张倩
Owner SICHUAN UNIV
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