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Chitosan microcapsule, its preparation method and uses

A technology of chitosan and chitosan solution, applied in the field of chitosan, can solve the problems of controlled release of unfavorable drugs, large particle size of chitosan microcapsules, loose microcapsule structure, etc., and achieve low cost and good particle size distribution Uniform, easy-to-process results

Inactive Publication Date: 2006-03-29
INST OF PROCESS ENG CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, organic reagents such as glutaraldehyde and epichlorohydrin are cytotoxic, and long-term use is harmful to the human body; chitosan microcapsules prepared by cross-linking with sodium tripolyphosphate have large particle size, low cross-linking degree, and loose microcapsule structure , not conducive to the controlled release of the drug

Method used

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  • Chitosan microcapsule, its preparation method and uses
  • Chitosan microcapsule, its preparation method and uses
  • Chitosan microcapsule, its preparation method and uses

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] Chitosan was dissolved in 0.2mol / L acetic acid solution to prepare a 2% (w / v) solution, 50mL of liquid paraffin was added to the reactor, 1mL of Span 80 was added, and the stirring speed was 1500 rpm. After dispersing for 10 minutes, add 10 mL of chitosan solution and continue to stir and disperse for 20 minutes, then add 50 mL of acetone dissolved in 200 mg of vanillin for cross-linking reaction, and stop after 1 hour. The reaction mixture was centrifuged, the reaction product was fully washed with petroleum ether, and the microcapsules were obtained after vacuum drying at room temperature. It can be used to embed proteins, polypeptide active macromolecular drugs and common drugs for colon targeted drug delivery.

Embodiment 2

[0035] Chitosan was dissolved in 0.2mol / L acetic acid solution to prepare a 3% (w / v) solution, 100mg naproxen was dispersed in the above 10mL chitosan solution, stirred, and 50mL liquid paraffin was added to the reactor In the process, continue stirring at a speed of 1000 rpm. After 20 minutes, add 60 mL of acetone dissolved in 1 g of vanillin for cross-linking, and stop the reaction after 1.5 hours. The reaction mixture is centrifuged, and the reaction product is fully washed with sherwood oil, and after vacuum drying at room temperature, the chitosan microcapsules embedded with naproxen are obtained, and the microcapsule particle diameter is about 750um (such asfigure 1 ). The release profile of the microcapsules in a pH=5 buffer solution simulating the colonic environment is as follows: image 3 As shown, the microcapsule has the effect of colon-targeted drug release control.

Embodiment 3

[0037] Chitosan was dissolved in 0.2mol / L acetic acid solution to prepare a 3% (w / v) solution, 100mg naproxen was dispersed in the above 10mL chitosan solution, stirred, and 50mL liquid paraffin was added to the reactor Add 1mL of Span 80, add the above dispersion system, continue stirring at 1000 rpm, after 20 minutes, add 60mL of acetone dissolved in 1g of vanillin for cross-linking, and stop the reaction after 1.5 hours. The reaction mixture is centrifuged, and the reaction product is fully washed with sherwood oil, and after vacuum drying at room temperature, the chitosan microcapsules embedded with naproxen are obtained, and the microcapsule particle diameter is about 430um (such as figure 2 ). The release profile of the microcapsules in a pH=5 buffer solution simulating the colonic environment is as follows: Figure 4 It shows that the microcapsule has the effect of colon-targeted drug release control.

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Abstract

The invention belongs to the field of chitosan, in particular a process for preparing microcapsule by cross bonding vanillic aldehyde (microcapsule) and chitosan, and the use of the chitosan microcapsule in protein, polypeptide macromolecular medicament and common medicament colon targeting medicine administration, the microcapsule is prepared from vanillic aldehyde cross bonding chitosan.

Description

technical field [0001] The invention belongs to the field of chitosan, in particular to a chitosan microcapsule and a method for preparing the microcapsule by chitosan cross-linked with vanillin (vanillin), and the chitosan microcapsule is used in proteins and polypeptides. Application in colon-targeted drug delivery of molecular drugs and common drugs. Background technique [0002] Colon-targeted drug delivery technology is an important branch of gastrointestinal drug delivery technology, which has developed rapidly since the 1990s. The colon-targeted drug delivery system was developed for the following reasons: [0003] 1. Traditional oral or rectal administration not only has relatively high toxicity and side effects, but also has problems such as poor specificity and difficulty in being accepted by patients. However, colon-targeted administration can directly deliver the drug to the affected area, which can improve the efficacy or reduce the do...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K47/36A61K9/50C08F251/00C08L5/08B01J13/02
Inventor 李巧霞宋宝珍
Owner INST OF PROCESS ENG CHINESE ACAD OF SCI
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