Preparation containing Gingkolactone and its producing process
A technology for ginkgolide and injections, which is applied in the field of injections containing ginkgolides, and can solve problems such as the method of not finding the content of active ingredients, affecting product stability and clinical efficacy, etc.
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[0111] prescription:
[0112] Ginkgolide 5.0g
[0113] Meglumine 5.0g
[0114] NaCl 8.0g
[0115] 10% citric acid solution appropriate amount
[0116] Preparation method: Take meglumine and add 1000ml of fresh water for injection to dissolve, autoclave at 120°C for 30 minutes, take it out, heat it to 80°C in a 10,000-grade batching room, add ginkgolide (ginkgolide) that has been ground and passed through a 80-mesh sieve Conform to the quality standard described in the present invention), be heated to dissolve, adjust pH to 8.0 with 10% citric acid aqueous solution after cooling to room temperature, add NaCl 8.0g, needle-use activated carbon 2.0g, room temperature stirring adsorption 30min, filter carbon removal, Add fresh water for injection to a total of 1000ml, filter with a 0.22μm microporous membrane under a sterile filter plate in a 100-level aseptic workshop, pack in 10ml ampoules, melt seal, quality check, print, and pack.
[0117] This product is a sterile aqueous ...
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