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Method for preparing pure oleum fructus brucease

The technology of bruce japonica and brucei japonica is applied in the field of extraction and preparation of extracting pure bruce chinensis oil, an anticancer active ingredient in bruce japonica fruit, can solve problems such as inability to purify completely, and achieve the effects of easy large-dose production, low cost and simple process

Inactive Publication Date: 2007-05-09
卞力
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0007] The purpose of the present invention is to overcome the deficiency that the existing extraction process of Brucea javanica oil cannot be thoroughly purified, to increase the crude oil purification step in the original process, to completely remove toxic water-soluble components in Brucea javanica and not to contain any plant residues such as chlorophyll , soluble cellulose, providing a method for the extraction and preparation of brucea javanica oil with a purity of 100%, thereby providing a safe and effective pure brucea javanica oil raw material for preparing javanica javanica oil emulsion injection

Method used

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  • Method for preparing pure oleum fructus brucease

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] Raw material: Brucea javanica fruit; Petroleum ether 60℃~90℃AR

[0031] Activated carbon (medicinal; bake at 160°C for 1h)

[0032] Kaolin (pharmaceutical grade; bake at 160°C for 1h)

[0033] (1) Pulverize: select ripe, dry fruit of Brucea javanica to cut off the stem impurity, be ground into coarse powder (20 mesh sieves), take by weighing coarse powder 25Kg,

[0034] (2) Petroleum ether extraction: Add 200L of petroleum ether, soak in a closed container for 9 hours (stir fully 2 times per hour), filter, collect the filtrate, add 150L of petroleum ether to the residue of Brucea javanica, soak in a closed container for 9 hours, (per hour Fully stir 2 times in 1 hour), collect filtrate, merge twice filtrate stand-by;

[0035] (3) Crude oil preparation: distill step (2) gained filtrate, heat and reclaim sherwood oil, until no liquid drop flows out, get dark green Brucea javanica crude oil 10L;

[0036] (4) Refining: heat the dark green javanica javanica crude oil obta...

Embodiment 2

[0039] Raw material: Dried Brucea javanica fruit; Petroleum ether 60℃~90℃AR

[0040] Activated carbon (medicinal; bake at 160°C for 1h)

[0041] Kaolin (pharmaceutical grade; bake at 160°C for 1h)

[0042] (3) pulverize: select ripe, dry fruit of Brucea javanica to cut off the stem impurity, be pulverized into coarse powder (20 mesh sieves) with pulverizer, weigh coarse powder and be 25Kg,

[0043] (4) Petroleum ether extraction: Add petroleum ether 200L, soak in a closed container for 8 hours (stir fully 2 times per hour), filter, collect the filtrate, add petroleum ether 150L in the Brucea javanica residue, and soak in a closed container for 8 hours, (per hour Fully stir 2 times in 1 hour), collect filtrate, merge twice filtrate stand-by;

[0044] (3) Crude oil preparation: distill the filtrate gained in step (2), heat and recover sherwood oil, until no liquid drops flow out, get dark green Brucea javanica crude oil 9.6L;

[0045](4) Refining: heat the dark green javanica...

Embodiment 3

[0048] Raw materials: dry and uniform fruit of javanica javanica; petroleum ether 60℃~90℃

[0049] Activated carbon (medicinal; bake at 160°C for 1h)

[0050] Kaolin (pharmaceutical grade; bake at 160°C for 1h)

[0051] (1) pulverize: select ripe, dry fruit of Brucea javanica to cut off the stem impurity, be pulverized into coarse powder (20 mesh sieves) with pulverizer, take by weighing coarse powder 25Kg,

[0052] (2) Oil ether extraction: Add petroleum ether 200L, soak in a closed container for 10 hours (stir fully 2 times per hour), filter, collect the filtrate, add petroleum ether 150L to the residue of Brucea javanica, soak in a closed container for 10 hours, (per hour Fully stir 2 times in 1 hour), collect filtrate, merge twice filtrate stand-by;

[0053] (3) Crude oil preparation: distill step (2) gained filtrate, heat and reclaim sherwood oil, until no liquid drop flows out, get dark green Brucea javanica crude oil 10L;

[0054] (4) Refining: Heating the dark green...

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Abstract

A process for preparing brucea fruit oil used to prepare injection includes breaking brucea fruit, extracting in petroleum ether to obtain coarse oil, heating, adding activated carbon, stirring, vacuum extracting to obtain yellow coarse oil, adding kaolinite, stirring vacuum extracting to obtain brucea fruit oil, and introducing N2 at 90-120 deg.C under vacu9um for 0.5-2 hrs to obtain high-purity brucea fruit oil.

Description

(1) Technical field [0001] The invention relates to an extraction process of oil-soluble plant activity, in particular to a preparation method for extracting pure javanica javanica oil, an anticancer active ingredient in fruit of javanica javanica. (2) Background technology [0002] Brucea javanica, another name is old javanica, flavescens, bitter in taste, poisonous. It is the dry and mature fruit of Brucea javanico(L)Merr, a plant of the bitter wood family. It is produced in Guangdong, Hainan, Guangxi, Fujian and other places in my country. It is harvested when the fruit is ripe in autumn, and the impurities are removed and dried in the sun. The main functions are heat-clearing, damp-damp, insecticide, detoxification, corrosion of chelicerae. In ancient my country, it was widely used in the treatment of amoebic dysentery. Since 1950, many scholars have used javanica oil to treat external auditory canal papilloma, laryngeal papilloma, and cervical cancer. In 1972, it was...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C11B1/10
Inventor 卞如廉卞力
Owner 卞力