Method for detecting syphilis using synthetic antigens

An antigen and composition technology, applied in the fields of microbiology and immunology, can solve the problems of time-consuming, expensive and other problems that cannot be used as a test to detect the success of antibiotic treatment
CN1353815AInactive Publication Date: 2002-06-12UNITED STATES OF AMERICA
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
UNITED STATES OF AMERICA
Publication Date
2002-06-12
Estimated Expiration
Not applicable · inactive patent
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Abstract

An antigen composition and method for the detection of antibodies to Treponema pallidum and the diagnosis of syphilis are described. The antigen composition contains synthetic cardiolipin and synthetic lecithin. The antigen composition may additionally contain cholesterol and an alcohol. The antigen composition is useful as an immunoreagent in immunoassays for the detection of antibodies associated with T. pallidum infection. The methods are sensitive and specific for T. pallidum infection.
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Description

[0001] This invention was made by a United States government agency, the Centers for Disease Control and Prevention. field of invention

[0002] The present invention relates to the fields of microbiology and immunology, and more particularly, to compositions and methods for detecting, diagnosing and monitoring the treatment of syphilis. In particular, the present invention relates to synthetic cardiolipin and lecithin antigen compositions and their use in immunoassays. Background of the invention

[0003] Syphilis is a sexually transmitted disease (STD) caused by the bacterium Treponema pallidum. Worldwide, more than 100,000 cases of syphilis in adults are reported annually. The disease can also be transmitted congenitally, infecting 3000 or more infants each year. When antibiotic treatment is not given in the early stages of a blight, the disease can spread throughout the body, often leading to irreversible damage to organs, mental illness, blindness or death. The world...

Claims

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