Treatment of human herpesviruses using hyperthermia

A herpes virus, herpes virus infection technology, applied in the direction of heating appliances for therapeutic treatment, cooling appliances for therapeutic treatment, antiviral agents, etc.

Inactive Publication Date: 2002-12-04
FIRST CIRCLE MEDICAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, these treatments are not effective for all patients, so there is still a need for better ways to treat human herpesvirus infections

Method used

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  • Treatment of human herpesviruses using hyperthermia
  • Treatment of human herpesviruses using hyperthermia
  • Treatment of human herpesviruses using hyperthermia

Examples

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Embodiment

[0044] The patient treated was a 38-year-old HIV / AIDS patient who was refractory to HIV drug therapy. The patient underwent one round of extracorporeal whole body hyperthermia (EWBH). The patient had been taking HIV medications prior to treatment for hyperthermia and was discontinued during treatment and during follow-up thereafter.

[0045] Response to drug therapy means that the patient is not responding to: (A) HIV PCR viral load ≥10,000 on stable antiviral therapy, and (B) a combination of two or more of the following three classes of antiviral drugs is not effective for them: two Nucleotide analogue, a non-nucleotide reverse transcriptase inhibitor and a protease inhibitor. Patients received a round of hyperthermia therapy during which their core body temperature was raised to 41.8 ± 0.2°C (maximum) for 90 minutes.

[0046] The patient was diagnosed with HIV in 8 / 88 and KS in 12 / 95. Although he has been receiving cryotherapy and vinblastine treatment in the lesion, 15 ...

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Abstract

The present invention provides a method for treating patients with human herpes virus infection, comprising: raising the patient's core body temperature at least once and then returning to normal, the core body temperature is raised to a temperature and duration sufficient to reduce or eliminate the patient's human herpes virus load.

Description

field of invention [0001] The present invention relates to a method for superheating human herpes virus. Background of the invention [0002] Human herpesviruses can cause many diseases such as chickenpox, examples of which include E-B virus, human cytomegalovirus, varicella-zoster virus, herpes simplex virus-1 or herpes simplex virus-2. It was recently discovered that human herpesvirus-8 (HHV-8) may cause Kaposi's sarcoma (KS). [0003] In order to infect the body's tissues and cells, viruses have developed a variety of ways to evade or fool the immune system. Human herpesviruses use latency to defend the immune system. Latency is the ability to not exhibit activity under conditions unsuitable for reproduction or growth. The key to eradicating such viruses is forcing them to actively reproduce when conditions are not favorable. [0004] Current methods for treating human herpes virus infection include the use of drugs such as acyclovir, cido...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61F7/00A61F7/12A61K31/513A61K31/704A61K31/7052A61K38/00A61K45/00A61M1/36A61P31/22
CPCA61F7/12A61F2007/126A61M1/369A61P31/22
Inventor K·格罗思T·凯利T·韦斯特贝克G·布利克
Owner FIRST CIRCLE MEDICAL
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