Hydrolyzation process of pearl powder suitable for ophthalmic medication

Abstract

The pearl powder hydrolyzing process suitable for preparing eye medicine preparation includes the steps of: weighing pearl powder of 60-300 mesh, adding pure water in 2-20 times pearl powder weight, hydrolysis under weak alkali condition through stirring inside reactor; heating to 60-120 deg.c, maintaining at the temperature for 1-3 days while stirring for several min every other 2-5 hr; cooling, filtering and concentrating the filtrate to 0.1-0.25 original volume. The hydrolysate has high stability, pH value of 9.6-10.8 beneficial to the further processing and simple preparing process.

Description

technical field

[0001] The invention relates to a process for hydrolyzing pearl layer powder, in particular to a process for hydrolyzing pearl layer powder suitable for ophthalmic medicine. Background technique

[0002] Existing pearl layer powder hydrolyzate technology has: acid hydrolysis, alkali hydrolysis and first alkalization and then the replacement reaction method with organic acid: 1, acid hydrolysis: common hydrochloric acid is boiled at 110 ℃ and refluxed for 16-24 hours or pressurized in Hydrolysis at 120°C for 12 hours, the advantages of hydrolysis with hydrochloric acid are (1) The best way to remove hydrochloric acid is heating and evaporation. (2) The hydrolysis is complete and can be completely converted into amino acids without causing optical isomerization of amino acids, and the product is still L-type. But the defect in the above technique is that (1) hydrochloric acid (volatile acid) removes HCL very easily in the air when heating and evaporating, and ...

Examples

Embodiment 1

[0015] Weigh 100 grams of pearl layer powder that can pass through a 60-mesh to 200-mesh sieve, add the pearl layer powder to 300ml-2000ml of purified water, stir well to form a suspension, and place it at a specific temperature (60°C-120°C) for reaction In the pot, keep this temperature for 1-3 days, stir once every 1-2 hours, 10-20 minutes each time, after fully hydrolyzed, until cold, take the supernatant and concentrate to a concentration of 1:4, let it cool and filter. PH value is 9.6-10.8;

Embodiment 2

[0017] Take 100 grams of pearl layer powder that can pass through a 60-mesh to 200-mesh sieve, add purified water (200ml-2000ml) while stirring, and stir well, put it in a 100°C reaction pot, and maintain this temperature state for 1- For 3 days, stir once every 1-3 hours, each time for 15-25 minutes, hydrolysis lasts for 1-3 days, until cold, filter, take the supernatant and concentrate to a concentration of 1:4-10, let it cool, filter After that, its pH value is 9.0-11.0, and then 200ml of water constant volume measures the total N amount ≥ 0.028% (g / ml) to sterilize to obtain the nacre powder hydrolyzate;

technical field

[0001] The invention relates to a process for hydrolyzing pearl layer powder, in particular to a process for hydrolyzing pearl layer powder suitable for ophthalmic medicine. Background technique

[0002] Existing pearl layer powder hydrolyzate technology has: acid hydrolysis, alkali hydrolysis and first alkalization and then the replacement reaction method with organic acid: 1, acid hydrolysis: common hydrochloric acid is boiled at 110 ℃ and refluxed for 16-24 hours or pressurized in Hydrolysis at 120°C for 12 hours, the advantages of hydrolysis with hydrochloric acid are (1) The best way to remove hydrochloric acid is heating and evaporation. (2) The hydrolysis is complete and can be completely converted into amino acids without causing optical isomerization of amino acids, and the product is still L-type. But the defect in the above technique is that (1) hydrochloric acid (volatile acid) removes HCL very easily in the air when heating and evaporating, and ...

Examples

Embodiment 1

[0015] Weigh 100 grams of pearl layer powder that can pass through a 60-mesh to 200-mesh sieve, add the pearl layer powder to 300ml-2000ml of purified water, stir well to form a suspension, and place it at a specific temperature (60°C-120°C) for reaction In the pot, keep this temperature for 1-3 days, stir once every 1-2 hours, 10-20 minutes each time, after fully hydrolyzed, until cold, take the supernatant and concentrate to a concentration of 1:4, let it cool and filter. PH value is 9.6-10.8;

Embodiment 2

[0017] Take 100 grams of pearl layer powder that can pass through a 60-mesh to 200-mesh sieve, add purified water (200ml-2000ml) while stirring, and stir well, put it in a 100°C reaction pot, and maintain this temperature state for 1- For 3 days, stir once every 1-3 hours, each time for 15-25 minutes, hydrolysis lasts for 1-3 days, until cold, filter, take the supernatant and concentrate to a concentration of 1:4-10, let it cool, filter After that, its pH value is 9.0-11.0, and then 200ml of water constant volume measures the total N amount ≥ 0.028% (g / ml) to sterilize to obtain the nacre powder hydrolyzate;