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Ribavirin gel as eye medicine and its production process

A ribavirin and production process technology, applied in the field of ophthalmic preparations, can solve the problems of drug loss, frequent administration times, poor clinical efficacy and the like

Inactive Publication Date: 2004-09-08
NANJING UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to the large amount of drug loss in the blink of an eye and the frequent administration times, it needs to be instilled every 2 hours, and the clinical effect is not good.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0012] Specific embodiments of the present invention take the preparation of 1000g ribavirin as an example.

[0013] Sprinkle 3g of Carbopol941 in 500ml of water for injection, disperse evenly, let it sol overnight, adjust the pH to 6.9 with 10mol / l NaOH (about 3ml). Weigh 1.0g of ribavirin into 200ml of water for injection, stir until completely dissolved, filter through a 0.22um microporous membrane, add the filtrate to the crude glue, and stir until uniform. Weigh 0.5g of ethyl p-hydroxybenzoate into 200ml of water for injection, heat and stir in a water bath until completely dissolved, add it to the glue, and stir evenly. Add water for injection to 1000g, and measure pH6.9. Seal the prepared glue with kraft paper and sterilize at 121°C for 10 minutes. After 2 hours of ultraviolet irradiation in a sterile laboratory, pour the eye gel into the aluminum tube with a 20ml syringe, 5g each, and seal it.

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PUM

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Abstract

The present invention belongs to the field of eye medicine preparation technology. The Ribavirin gel as eye medicine consists of Ribavirin in 0.1 %, Carbopol 941 0.3 % and Nipagin A 0.05 % except injection water. The production process of the Ribavirin gel preparation includes spreading Carbopol 941 as gel matrix into water, letting stand over night for fully swelling to form coarse gel, regulate pH to 5-9 with NaOH, adding Ribavirin medicine liquid and Nipagin A as preservative to prepare the gel preparation. The gel preparation is normally liquid state and, after contacting with cation in tear, will become gel to act in conjunctival sac. The gel has effective lubricating effect and powerful adhesion, and this increases the area and time of contact between medicine and eye, increases medicine absorption and raises the curative effect of the medicine.

Description

1. Technical field [0001] The invention belongs to the technical field of ophthalmic preparations. 2. Background technology [0002] Ribavirin, also known as ribavirin or ribavirin, is a broad-spectrum antiviral drug. It was first artificially synthesized in 1970, launched in Mexico in 1974, and successfully developed in China in 1981. Since 1985, the research, development and application of its raw materials and preparations have developed rapidly. Existing tablet, capsule, spray, eye drop, eye ointment, oral liquid, oral gel and ribavirin compound preparation come out. [0003] Ribavirin eye drops are effective in preventing and treating eye infections, and are often used clinically in the treatment of herpes simplex virus keratitis, vaccinia and acute epidemic conjunctivitis. However, due to the large amount of drug loss in the blink of an eye and the frequent administration times, it needs to be instilled every 2 hours, and the clinical effect is not good. 3. Conten...

Claims

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Application Information

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IPC IPC(8): A61K9/00A61K31/7056A61P27/02A61P31/12
Inventor 胡一桥曹维
Owner NANJING UNIV