Curcumin injection and method for preparing the same

A technology of curcumin and injection, which is applied in the field of traditional Chinese medicine and pharmaceuticals, can solve the problems of curcumin instability and other problems, and achieve the effect of no toxic and side effects

Inactive Publication Date: 2004-11-10
张晴龙
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0010] The present invention aims at the defects of curcumin being insoluble in water and light instability, by compounding curcumin and compounding agent, a complex of curcumin and compounding agent is formed, the solubility of curcumin in water is increased, and curcumin improves light stability properties, the solubility of curcumin in water is increased from <0.1mg / ml (almost insoluble in water) to 1-10mg / ml, and on this basis, it is prepared into curcumin injection preparations, especially prepared into intravenous injections, including different Volume injection and lyophilized powder injection

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0113] Embodiment 1 (infusion solution)

[0114] 1 Take 500g of hydroxypropyl β-cyclodextrin, add 2500ml of water for injection, put it in a 50°C bath, stir to dissolve;

[0115] 2 Take another 5g of curcumin, add 100ml of 70% ethanol, stir to dissolve;

[0116] 3. Slowly add the curcumin ethanol solution into the hydroxypropyl β-cyclodextrin solution in a water bath at 70-80°C while stirring, and continue stirring for 1 hour;

[0117] 4 Add 90g of sodium chloride, stir to dissolve, then add water for injection to 10000ml;

[0118] 5. Filter through No. 6 sand core board, pack into 50ml bottles, 100ml bottles, sterilize at 115°C for 30 minutes, pack, and get ready.

Embodiment 2

[0119] Embodiment 2 (freeze-dried powder injection)

[0120] 1 Take 1.25kg of hydroxypropyl β-cyclodextrin, add 5000ml of water for injection, heat in a water bath at 50°C, and stir to dissolve;

[0121] 2 Take another 12.5g of curcumin, add 200ml of 95% ethanol, stir to dissolve;

[0122] 3. Slowly add the curcumin ethanol solution into the hydroxypropyl β-cyclodextrin solution in a water bath at 70-80°C while stirring, and continue stirring for 2 hours;

[0123] 4 Add mannitol, glucose 250g and appropriate amount of water for injection, stir to dissolve, then add water for injection to 10000ml;

[0124] 5 Sterile filtration, subpackaging into vials of 20ml each, freeze-drying, packaging, to obtain.

Embodiment 3

[0126] 1 Take 2kg of hydroxypropyl β-cyclodextrin, add 5000ml of water for injection, heat in a water bath at 50°C, and stir to dissolve;

[0127] 2 Take another 20g of curcumin, add 250ml of 80% ethanol, stir to dissolve;

[0128] 3. Slowly add the curcumin ethanol solution into the hydroxypropyl β-cyclodextrin solution in a water bath at 70-80°C while stirring, and continue stirring for 2 hours;

[0129] 4 Add 90g of sodium chloride and an appropriate amount of water for injection, stir to dissolve, and add water for injection to 10000ml;

[0130] 5. Filter through No. 6 sand core board, pack into 50ml bottles, sterilize at 115°C for 30 minutes, and pack.

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Abstract

The invention relates to a curcumin injection comprises the complex of curcumin and macromolecular complexing agent of hydroxyl propyl beta-cyclodextrin having polyhydroxy, water-soluble medicinal findings for injection and / or freeze-drying excipient, the dosage form includes transfusion and freeze dried. The invention also provides the process for preparing the curcumin injection, which can be used in the treatment for cancer, leukemia, hepatic diseases and cranial vascular diseases.

Description

Technical field [0001] The invention belongs to the technical field of traditional Chinese medicine pharmacy, and in particular relates to a curcumin injection preparation and a preparation method of the preparation. technical background [0002] Curcumin is the main active ingredient of the traditional Chinese medicine curcumin. Since ancient times, turmeric has been widely used as a food additive. With the advancement of modern technology and the deepening of people's understanding of curcumin, curcumin has been found to have a wide range of medicinal effects. Animal experiments have shown that curcumin has various therapeutic effects such as anti-cancer, anti-oxidation, lowering blood fat, inhibiting thrombosis, removing peroxides, and sensitizing anti-tumor drugs. Therefore, curcumin has also become a hot spot in drug research at home and abroad. There have been reports of solid medicinal preparations of curcumin in domestic literature, but no reports of curcumin inje...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/08A61K31/122A61P1/16A61P9/00A61P35/00
Inventor 张晴龙
Owner 张晴龙
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