Injection of still-freeze drying powder for restoring consciousness and new preparation method

A technology for Xingnaojing and injection, which is applied in the field of freeze-dried powder of Xingnaojing for injection and its preparation, can solve the problems of changing pH value, not being very clear about the effective part of Xingnaojing injection, and not being suitable for application, etc., to achieve good results Practical, simple and feasible process operation

Inactive Publication Date: 2005-01-12
秦吉兴
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But there is certain shortcoming in existing preparation technology (Ministry of Public Health Chinese patent medicine preparation ministerial standard 17th subvolume), especially the extraction of musk only adopts steam distillation to extract, and musk is a famous and precious Chinese medicine, and the price is high, so there is a large waste, the current technology only extracts turmeric and gardenia by steam distillation, which has not reached the full utilization of these two medicines; in the technology, borneol is solubilized by Tween-80, which has hemolytic properties effect, so it should not be used in intravenous injection
In addition, the effective part of Xingnaojing injection is not very clear. The quality standard only requires borneol, but not other active ingredients. In addition, due to the poor stability of the injection, it is often stored for a certain period of time. The pH value changes, the appearance color becomes darker, and even turbidity and precipitation appear, which makes the clarity unqualified. Therefore, the process of Xinnaojing injection needs to be improved and improved.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0082] 1. Prescription: musk 7.5g, turmeric 30g, borneol 1g, gardenia 30g

[0083] 2. Extraction process:

[0084] Get turmeric, grind it into coarse powder, extract twice with 6 times the amount of 80% ethanol, the first time for 2 hours, the second time for 1 hour, filter, combine the extracts, and the filtrate decompresses to reclaim ethanol, and concentrate to a relative density of 1.10 (50°C) extract, the extract is extracted 6 times with an equal amount of ethyl acetate, the ethyl acetate extract is combined, the ethyl acetate is recovered under reduced pressure, and concentrated to an extract with a relative density of about 1.20 (50°C). paste, vacuum-dried to obtain 0.11g of turmeric extract; take gardenia decoction pieces, break the shell, and extract twice with 8 times the amount of 75% ethanol under reflux, the first time for 2 hours, the second time for 1 hour, filter, and combine the extracts, Ethanol is recovered from the filtrate under reduced pressure, and con...

Embodiment 2

[0087] 1. Prescription: musk 75g, turmeric 300g, borneol 10g, gardenia 300g

[0088] 2. Extraction process:

[0089] Take turmeric decoction pieces, crush them into coarse powder, extract twice with 6 times the amount of 80% ethanol, the first time for 2 hours, the second time for 1 hour, filter, combine the extracts, and recover the ethanol from the filtrate under reduced pressure, and concentrate to relative density The extract is about 1.20 (50°C), the extract is extracted 6 times with an equal amount of ethyl acetate, the ethyl acetate extract is combined, the ethyl acetate is recovered under reduced pressure, and concentrated to a relative density of about 1.30 (50°C). Extraction, vacuum-dried to obtain 1.12 grams of turmeric extract; take gardenia decoction pieces, break the shell, and extract twice with 8 times the amount of 75% ethanol under reflux, the first time for 2 hours, the second time for 1 hour, filter, and combine the extracts , the filtrate is decompressed ...

Embodiment 3

[0092] 1. Prescription: musk 750g, turmeric 3000g, borneol 100g, gardenia 3000g

[0093] 2. Extraction process:

[0094] Take turmeric decoction pieces, crush them into coarse powder, extract twice with 6 times the amount of 80% ethanol, the first time for 2 hours, the second time for 1 hour, filter, combine the extracts, and recover the ethanol from the filtrate under reduced pressure, and concentrate to relative density The extract is about 1.15 (50°C), the extract is extracted 6 times with an equal amount of ethyl acetate, the ethyl acetate extract is combined, the ethyl acetate is recovered under reduced pressure, and concentrated to a relative density of about 1.25 (50°C). Extraction, vacuum-dried to obtain 10.89 grams of turmeric extract; take gardenia decoction pieces, break the shell, and extract twice with 8 times the amount of 75% ethanol under reflux, the first time for 2 hours, the second time for 1 hour, filter, and combine the extracts , the filtrate is decompress...

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PUM

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Abstract

A freeze-dried powder injection for sobering brain up is prepared from musk, borneol, capejasmine fruit and curcuma root through extracting active components, adding hydroxypropyl-beta-cyclodextrin for inclusion, and freeze drying.

Description

Technical field [0001] The invention belongs to the technical field of traditional Chinese medicine pharmacy, and in particular relates to a Xingnaojing freeze-dried powder for injection and a new preparation method thereof. Background technique [0002] Hydroxypropyl-β-cyclodextrin (HP-β-CD for short) is a kind of hydroxyalkylated derivatives of β-cyclodextrin. In each glucose residue of β-cyclodextrin (β-CD), the hydrogen atoms of C-2, C-3 and C-63 hydroxyl groups can be replaced by hydroxypropyl groups (-CHCHOHCH), and 2- Homologs such as HP-β-CD, 3-HP-β-CD, 2,3-DHP-β-CD, 2,6-DHP-β-CD, 2,3,6-THP-β-CD. In general, the substitution reaction product is a mixture. If the conditions are controlled, products mainly composed of 2-HP-β-CD, 2,3-DHP-β-CD or 3-HP-β-CD can be produced. HP-β-CD is currently the CD derivative with the most research, the most sufficient work, the most comprehensive collection of safety data, and the best effect on drug solubilization and stability im...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/19A61K35/55A61P1/16A61P25/00A61P31/12
Inventor 秦吉兴
Owner 秦吉兴
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