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Dripping pills of andrographolide and its preparing method

A technology of andrographolide and ester dripping pills, which is applied in pill delivery, pharmaceutical formulations, medical preparations containing active ingredients, etc., and can solve problems such as slow disintegration speed of solid oral preparations, low release speed of ingredients, and reduction of active ingredients , to achieve the effect of small drop pills, easy to take, and easy to take

Inactive Publication Date: 2005-01-26
TIANJIN TASLY PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] ①Slow disintegration rate of solid oral preparations (such as tablets, capsules, etc.) and low release rate of active ingredients
Such a long time is undoubtedly not helpful for the rapid release of the active ingredients of the drug
[0007] ②First-pass effect problem
Due to its own reasons, oral preparations are mostly absorbed in the gastrointestinal tract, which is prone to first-pass effect, which reduces the active ingredients

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0068] a. Get andrographolide 150g;

[0069] b. Take 375g of polyethylene glycol (molecular weight: 4000), heat it to 85°C, add the above-mentioned andrographolide after melting, and mix well;

[0070] c. Move the above-mentioned andrographolide mixed with auxiliary materials into the dripping pill machine for drip irrigation and keep it at 65°C, drop the medicine solution into the liquid paraffin at 9°C, take out the dripping pills, wipe the pills, and dry them in the air;

[0071] d. Film-coat the dropping pills obtained above to increase the weight by 4%, and make 875 bags. The coating conditions are as follows: tablet bed temperature is 30° C.; atomization pressure is 2 bar; feed flow rate is 3 g / min.

Embodiment 2

[0073] a. Get andrographolide 150g;

[0074] b. Take 375g of polyethylene glycol (molecular weight: 6000), heat it to 85°C, add the above-mentioned andrographolide after melting, and mix well;

[0075] c. Move the above-mentioned andrographolide mixed with auxiliary materials into the dripping pill machine for drip irrigation and keep it at 65°C, drop the medicine solution into the liquid paraffin at 6°C, take out the dripping pills, wipe the pills, and dry them in the air;

[0076] d. Film-coat the dropping pills obtained above to increase the weight by 4%, and make 875 bags. The coating conditions are as follows: tablet bed temperature is 30° C.; atomization pressure is 2 bar; feed flow rate is 3 g / min.

Embodiment 3

[0078] a. Get andrographolide 150g;

[0079] b. Take 375g of polyethylene glycol mixture (PEG6000:PEG4000=1:0.5), heat it to 85°C, add the above-mentioned andrographolide after melting, and mix well;

[0080] c. Move the above-mentioned andrographolide mixed with auxiliary materials into the dripping pill machine for drip irrigation and keep it at 65°C, drop the medicine solution into the liquid paraffin at 9°C, take out the dripping pills, wipe the pills, and dry them in the air;

[0081] d. Film-coat the dropping pills obtained above to increase the weight by 4%, and make 875 bags. The coating conditions are as follows: tablet bed temperature is 30° C.; atomization pressure is 2 bar; feed flow rate is 3 g / min.

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PUM

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Abstract

The invention discloses dripping pills of andrographolide and its preparing method, wherein the andrographolide is filed by right amount of findings to obtain drop pills. The invention also discloses the pharmaceutical actions of the traditional Chinese medicine.

Description

technical field [0001] The invention relates to a traditional Chinese medicine preparation, in particular the invention relates to an andrographolide dropping pill preparation, and the invention also discloses a preparation method thereof. Background technique [0002] Andrographolide, also known as andrographolide, is a colorless square, rectangular or prism-shaped crystal, and is a diterpene lactone compound extracted from Andrographis paniculata. It is recorded in the Pharmacopoeia of the People's Republic of China [1997 edition]. Clinically, it is widely used in the treatment of various infections and non-infectious inflammatory diseases, especially for intestinal and respiratory infections. [0003] In terms of intestinal infection, andrographolide has a certain effect on acute and chronic enteritis, bacillary dysentery, typhoid fever and intestinal trichomoniasis, but it is better for acute bacillary dysentery and acute enteritis. [00...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/20A61K31/365A61P1/00A61P11/00A61P31/04
Inventor 童玉新叶正良汪豪顾菲菲孙延标芮绍照叶寿山
Owner TIANJIN TASLY PHARMA CO LTD
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