Nicergoline oral cavity disintegration tablet and its preparation method

A technology of oral disintegrant and nicergoline, which is applied in the directions of pill delivery, nervous system diseases, active ingredients of heterocyclic compounds, etc., and can solve the problems such as no oral disintegrant.

Active Publication Date: 2005-03-09
HAINAN PULIN PHARMA +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the dosage forms of nicergoline are mainly tablets and capsules, and there is no report of an oral disintegrating agent on the market

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0008] The present invention will be further described below through specific examples, but the present invention is not limited by the examples.

[0009] Embodiment: 10.0g of Nicergoline and Eudragit L30D (methacrylic acid copolymer resin) 40.0g are added in the blender, fully wetted with water, stirred with 500 rev / mins in the blender, it is completely mixed. Then it was dried in an oven at 45°C until constant weight. The dried product is then pulverized to a particle size suitable for tableting. Add to V-shaped mixer, then add compressible sorbitol 380.0g, citric acid 15.5g, sodium bicarbonate 50.0g, magnesium stearate 2.5g, silicon dioxide 0.5g, lemon flavor 1.5g, mix well . A tablet with a tablet weight of 500 mg was compressed using a common tablet press.

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PUM

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Abstract

An oral disintegrating tablet of nicergoline contains nicergoline and auxiliaries including sorbitol, methylacryl copolymer resin (Eudragit L30D), citric acid, sodium dicarbonate, magnesium stearate, SiO2 and lemon perfume.

Description

technical field [0001] The invention relates to a dosage form of medicine, in particular to a nicergoline oral disintegrating agent and a preparation method thereof. technical background [0002] Oral disintegrating agents are very necessary for those who have difficulty swallowing, especially the elderly, children and the environment where water is inconvenient. Play a role. Orally rapidly disintegrating tablets are high-porosity oral preparations prepared by the British Weyth Company (Weyth) using freeze-drying technology in the late 1970s, and developed rapidly in the 1990s. Nicergoline has α-receptor blocking effect and vasodilator effect, which can strengthen the energy metabolism of brain cells, increase the utilization of oxygen and glucose; promote the conversion of neurotransmitter dopamine to increase nerve conduction, and strengthen the synthesis of brain proteins , good brain function. It is mainly used to improve cerebral arteriosclero...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/20A61K31/48A61P25/00A61P25/28
Inventor 范敏华
Owner HAINAN PULIN PHARMA
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