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Use of hemopoietic stem cell mobilizer in preparation of medicine for treating diabetes

A technology for hematopoietic stem cells and diabetes drugs, which is applied in the field of preparing drugs for treating diabetes, can solve the problems of difficulty in bone marrow cells, the danger of type I diabetes, etc., and achieves the effects of strong proliferation ability and high safety.

Inactive Publication Date: 2005-03-09
PEKING UNIV
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  • Claims
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AI Technical Summary

Problems solved by technology

[0005] However, there is still a certain distance between these research results and clinical application. Recipients of bone marrow transplantation need to undergo high doses of radiotherapy and chemotherapy, which is extremely dangerous for people with type 1 diabetes
Also, finding enough bone marrow cells to match the tissue type remains very difficult

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0023] 1. Preparation of diabetes model:

[0024] C57 mice, weighing 18-22 grams, were intraperitoneally injected with STZ (streptozotocin) at a dose of 35 mg / kg for five consecutive days.

[0025] 2. Hematopoietic mobilization:

[0026] Control group: inject normal saline.

[0027] Experimental group: From the tenth day of STZ injection, recombinant human granulocyte colony-stimulating factor (G-CSF) was subcutaneously injected at a dose of 200 vg / kg / day. Use it for five days.

[0028] 3. Conclusion:

[0029] Through the use of hematopoietic stem cell mobilization technology, a large number of hematopoietic stem cells in the bone marrow of diabetic animal models are released into the peripheral blood, so that these hematopoietic stem cells participate in the repair of pancreatic endocrine cells, thereby achieving the effect of reversing diabetes.

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PUM

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Abstract

An application of hemopoietic stem cells mobilizing agents including cell factor, especially the granulocyte colony simulating factor, in preparing the medicine for treating diabetes is disclosed.

Description

Technical field: [0001] The present invention relates to the application of hematopoietic stem cell mobilization agent, in particular to the application of preparing medicine for treating diabetes. Background technique: [0002] The treatment of diabetes (Diabetes Mellitus, DM) is one of the important contents of current medical research. In order to treat both symptoms and root causes, pancreas transplantation therapy has been developed rapidly in the past 30 years. But this therapy also has many problems. On the one hand, the source of donor pancreas is very tight and cannot meet the needs at all; on the other hand, the problem of immune rejection is very prominent, and the risk of large-scale abdominal surgery for diabetic patients is greater than the danger brought by diabetes itself. [0003] Isolation and purification of islets from donor pancreases is much safer than pancreas transplantation, but since enough islets can only be isolated from two donor pancreases for...

Claims

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Application Information

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IPC IPC(8): A61K38/19A61K45/00A61P3/10
Inventor 任立晨侯玲玲滕春波赵东昕丁明孝邓宏魁
Owner PEKING UNIV
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