Anti-fungus external-use agent for finger nail

An antifungal and topical agent technology, applied in antifungal agents, manicure, dressing preparations, etc., can solve problems such as many side effects, difficult treatment of onychomycosis, and liver function damage

Inactive Publication Date: 2005-05-04
HISAMITSU PHARM CO INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] However, the treatment of onychomycosis is very difficult, and now most of them are treated by oral antifungal drugs, but oral antifungal drugs have many problems such as liver function damage and other side effects

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] Embodiment 1 (patch)

[0035] Neconazole Hydrochloride 1.0g

[0036] Styrene-isoprene-styrene block copolymer 25.0g

[0037] Liquid paraffin 56.95g

[0038] Diethyl sebacate 5.0g

[0039] Rosin ester derivatives 5.0g

[0040] Sorbitan Sesquioleate 3.0g

[0041] Sodium hydroxide 0.12g

[0042] Purified water 2.88g

[0043] Dibutylhydroxytoluene 0.05g

[0044] Total 100g

[0045] Using a kneader as a mixer, heat and mix styrene-isoprene-styrene block copolymer, softener and rosin ester derivative at 120-160 ° C, then add and mix neconazole hydrochloride and sodium hydroxide A solution made by dissolving in purified water and other ingredients is spread directly on the polyester cloth. Then, it was covered with a polypropylene release film and cut to a desired size to obtain a patch.

Embodiment 2

[0046] Embodiment 2 (nail polish)

[0047] Neconazole Hydrochloride 5.0g

[0048] Ethyl cellulose 15.0g

[0049] Diethyl sebacate 10.0g

[0050] Polyoxyethylene (9) lauryl ether 2.0g

[0051] Diisopropanolamine 0.4g

[0052] Dibutylhydroxytoluene 0.05g

[0053] Acetone 32.55g

[0054] Add absolute ethanol to the total amount of 100g

[0055] Dissolve and mix neconazole hydrochloride, diethyl sebacate, polyoxyethylene (9) lauryl ether, diisopropanolamine, and dibutylhydroxytoluene in a mixed solution of absolute ethanol and acetone. Then, after dissolving ethyl cellulose, add absolute ethanol to a total amount of 100 g. Then the prepared nail polish was added to a glass container with a hairbrush to obtain a nail polish.

Embodiment 3

[0056] Embodiment 3 (paste)

[0057] Neconazole Hydrochloride 1.0g

[0058] Diisopropyl Adipate 5.0g

[0059] Sodium polyacrylate 2.0g

[0060] Polyacrylic acid 2.0g

[0061] Sodium Carboxymethyl Cellulose 3.0g

[0062] Propylene glycol 5.0g

[0063] Concentrated Glycerin 20.0g

[0064] D-sorbitol solution (70%) 35.0g

[0065] Light silica 4.0g

[0066] Dry Potassium Aluminum Sulfate 0.3g

[0067] Sodium EDTA 0.05g

[0068] Sodium hydroxide 0.12g

[0069] Purified water 22.53g

[0070] Total 100g

[0071] Using a stirrer as a mixer, disperse the sodium polyacrylate and polyacrylic acid into the mixture of concentrated glycerin. Separately, neconazole hydrochloride and sodium hydroxide were dissolved in a mixed solution of purified water and propylene glycol, and the solution and other ingredients were added to the dispersion and mixed to obtain a paste. Then, it is stretched directly on the polyester nonwoven fabric, covered with a polypropylene release film, and ...

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PUM

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Abstract

The present invention relates to an antifungal agent for external use for curing leuconychia. Said invented antifungal agent contains two components of A and B, in which the A is naphthocomzole or its salt and B is basic substance. Its effective component naphthocomzole has high osmolity for finger nail, so that said invented antifungal agent for external use has high therapeutic effect for curing leuconychia.

Description

technical field [0001] The present invention relates to an antifungal external preparation for nails with good drug permeability to nails and high therapeutic effect. Background technique [0002] In fungal infections of the skin, onychomycosis (also known as onychomycosis) has turbid or yellow-white turbid nails. As symptoms progress, deformation such as thickening occurs in the front of the nail. However, because there are no symptoms such as pain or itching, it often develops into deformation of the nail without realizing it. In addition, in patients with foot fungal infection or hand fungal infection, when the topical antifungal agent is used for treatment, symptoms often recur once the treatment is stopped after the symptoms are temporarily treated. This is because the treatment is discontinued when the fungus present in the deep part of the nail of the foot or hand does not die. Treating onychomycosis in a real sense is important. [0003] However, the treatment of...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/4164A61K8/49A61K9/00A61K31/4174A61K31/4178A61K47/02A61K47/08A61K47/10A61K47/12A61K47/14A61K47/18A61K47/26A61P31/10A61Q3/00
CPCA61Q3/00A61K8/4946A61K31/4164A61K31/4178A61K31/4174A61P31/10
Inventor 川濑一朗池田保夫原浩祐鸣井隆金子哲男
Owner HISAMITSU PHARM CO INC
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