Guaiamar dripping pill

A technology of guaiacol glycerin and dripping pills, which is applied in the fields of pill delivery, respiratory diseases, organic active ingredients, etc., and can solve the problem of inflexibility due to disease, individual conditions, hepatic first-pass effect, and increasing number of patients Economic burden and other issues, to avoid the first-pass effect of liver and intestines, improve bioavailability, and reduce economic burden

Inactive Publication Date: 2005-05-18
北京博智绿洲医药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to the characteristics of their preparation technology, tablets and capsules usually have problems such as long dissolution time, low dissolution rate, poor absorption, low bioavailability, and prone to hepatic and intestinal first-pass effects, which affect drug efficacy. full play
[0007] In addition, there is still the infl

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0035] Below in conjunction with two groups of specific embodiment tests, the preparation process and test results of the guaiacol glycerin ether dripping pills involved in the present invention are further described.

[0036] Example Test 1 Prescription experiment of guaiacol glycerin and different substrates

[0037] Experimental Design: In order to observe the influence of guaiacol glyceryl ether and different matrix prescriptions on the guaiacol glycerin dripping pills involved in the present invention, polyethylene glycol 2000 , polyethylene glycol 4000 , polyethylene glycol 6000 , polyethylene glycol 8000 , polyethylene glycol 10000 , stearic acid, sodium stearate, glycerin gelatin, polyoxyl 40 stearate, shellac, polyoxyethylene monostearate, polyether, sodium carboxymethyl starch, sodium lauryl sulfate, etc. Any one of the pharmaceutical excipients is used as a base, and the guaiacol glycerin and the above bases are formulated in a ratio of 1:4, and according to the...

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PUM

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Abstract

The present invention discloses a kind of cough-relieving and phlegm-eliminating medicine composition, and is especially orally taken medicine composition dripping pill with guaiamar as active component. The guaiamar dripping pill has great medicine carrying amount, fast medicine releasing, fast acting, high bioavailability, less toxic side effect, convenient taking and low cost. The guaiamar dripping pill is prepared with guaiamar as active component, and through adding medicinal carrier as matrix, heating to obtain melt and/or emulsion and/or suspension of guaiamar and matrix, and dropping into condensating agent in dripping pill machine to form through shrinking.

Description

technical field [0001] The invention relates to a pharmaceutical composition for relieving cough and removing phlegm, in particular to an oral preparation of the pharmaceutical composition with guaiacol as an active ingredient. Background technique [0002] According to statistics, respiratory diseases account for about 1 / 4 of internal medicine patients. In my country's population statistics, respiratory diseases are the second cause of death. The main symptoms of respiratory diseases are cough, sputum and asthma. In recent years, there are gradually more and more drugs available in clinical practice, and guaiacol is one of them. [0003] Guaifenesin (GF) is an expectorant, which can reduce the viscosity of sputum, reduce the foul smell of sputum, and relax smooth muscle. It is mainly used for cold, cough, bronchitis and other diseases in clinical practice. The drug is soluble in water and ethanol, and is rapidly absorbed in the gastrointestinal tract, with a peak time of a...

Claims

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Application Information

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IPC IPC(8): A61K9/20A61K31/085A61P11/10A61P11/14
Inventor 曲韵智
Owner 北京博智绿洲医药科技有限公司
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