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Medicinal composition contg. katopril, and its prepn. method

A composition and drug technology, applied in the pharmaceutical composition containing captopril and its preparation field, can solve the problems of high disulfide content, complicated process, unstable product content, etc., and achieve the effect of stable product content

Inactive Publication Date: 2005-05-25
SHANGHAI XUDONG HAIPU PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] One of the technical problems to be solved in the present invention is to disclose a pharmaceutical composition containing captopril, so as to overcome the defects of complex technological process, high production cost, unstable product content and high disulfide content in the prior art;

Method used

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  • Medicinal composition contg. katopril, and its prepn. method

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Embodiment 1

[0032] (1) Stir 6 kg of lactose, 1 kg of starch, 1.5 kg of pregelatinized starch, and 1 kg of hydroxypropyl cellulose, pass through a 16-mesh sieve, and add PVP with a weight percentage concentration of 5% by a method known in the art. It is a 50% ethanol solution, in which, 210 g of povidone K30 (PVP.k30) is wet granulated, dried at 80°C for 4 hours, dried for 2 hours and tumbled, and the granules are granulated through a 16-mesh sieve;

[0033] (2) 2.55 kg of captopril and 2.5 kg of microcrystalline cellulose were stirred evenly, passed through a 16-mesh sieve, dry-pressed for sizing, and the roller pressure of the dry press was set at 5Mpa;

[0034] (3) With the above two kinds of granules, add 0.1 kg of magnesium stearate and mix well.

[0035] Particle size: mesh

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Abstract

A composite medicine containing captopril is prepared from captopril, microcrystalline cellulose, lactose, starch, hydroxypropyl cellulose, pregelatinized starch, magnesium stearate and polyvidone K30 through respectively granulating and mixing.

Description

technical field [0001] The invention relates to a medicine for treating hypertension, in particular to a pharmaceutical composition containing captopril and a preparation method thereof. Background technique [0002] Captopril is a vasodilator with good antihypertensive effect, and its general structural formula is as follows: [0003] [0004] At present, there have been numerous literature reports on pharmaceutical compositions containing the active ingredient captopril and their preparation methods, but they are all wet granulated. Because the structure of captopril contains sulfhydryl groups, it contains Water will hydrolyze mercapto groups, increase harmful components, affect product quality, complex process, high production cost, unstable product content, high disulfide content, and cannot meet the needs of relevant parties, so it must be improved, developed and researched The new pharmaceutical composition containing captopril and its preparation method meet the n...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/16A61K31/4015A61P9/12
Inventor 施惠琴许宏志翁建平郭文荣
Owner SHANGHAI XUDONG HAIPU PHARMA
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