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Medicinal composition for preventing and treating hyperplasia of prostate and preparation method thereof

A prostatic hyperplasia and composition technology, which is applied in the direction of drug combinations, pharmaceutical formulas, and medical preparations containing active ingredients, can solve the problems of less in-depth research, poor repeatability of experimental results, and lack of uniform standards for research.

Inactive Publication Date: 2005-07-06
JIANGSU PROVINCE INST OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There are still problems in the treatment of BPH with traditional Chinese medicine: the lack of uniform standards in research, such as syndrome type, efficacy evaluation, etc.; poor repeatability of experimental results; more short-term clinical efficacy observations, but less mid-term and long-term clinical efficacy observations; There are many studies on the single active ingredient of the drug and special prescriptions for specific diseases, but few in-depth studies, which cannot give full play to the advantages of traditional Chinese medicine in the treatment of BPH

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] Prescription (daily volume): 13 grams of mulberry octopus, 15 grams of plantain seed, 10 grams of skullcap, 7.5 grams of Achyranthes bidentata, 5 grams of cinnamon, and 10 grams of buliuxing.

[0032] Take the medicinal materials according to the prescription amount, and set aside. Take cinnamon and extract the volatile oil by distillation, wrap the volatile oil with β-cyclodextrin, and store the dregs in a separate container. The ratio of volatile oil to β-cyclodextrin is 1:20 (1ml of cinnamon volatile oil is wrapped with 20 grams of β-cyclodextrin by weight), stirred at 80°C for 3 hours at a speed of 500 rpm, and set aside. The mother liquor was concentrated and dried in vacuum to obtain an extract for future use.

[0033] Take Scutellaria baicalensis and add water to decoct 3 times, add 12 times the amount (volume / weight of medicinal materials) water for the first time, add 10 times the amount (volume / weight of medicinal materials) for the second time, add 10 times ...

Embodiment 2

[0038] Prescription (daily volume): 6 grams of mulberry octopus, 8 grams of psyllium, 4 grams of skullcap, 6 grams of Achyranthes bidentata, 2 grams of cinnamon, and 6 grams of vaccum.

[0039] Take the medicinal materials according to the prescription amount, and set aside. Take cinnamon and extract the volatile oil by distillation, wrap the volatile oil with β-cyclodextrin, and store the mother liquor and dregs in a separate container. The ratio of volatile oil to β-cyclodextrin is 1:16 (1ml of cinnamon volatile oil is wrapped with 16 grams of β-cyclodextrin by weight), stirred at 75°C for 2 hours at 1000 rpm, and set aside.

[0040] Take Scutellaria baicalensis and add water to decoct 4 times, each time add 6 times the amount (volume / weight of medicinal material) to decoct with water for 0.5 hours, filter, combine the filtrate, concentrate to contain crude drug 3g / ml, centrifuge, and adjust the pH value of the centrifuged liquid with hydrochloric acid to 3. Incubate at 80°...

Embodiment 3

[0045] Prescription (daily volume): 12 grams of mulberry and octopus, 12 grams of plantain seed, 6 grams of skullcap, 6 grams of Achyranthes bidentata, 6 grams of cinnamon, and 12 grams of vaccinia.

[0046] Take the medicinal materials according to the prescription amount, and set aside. Take cinnamon and extract the volatile oil by distillation, wrap the volatile oil with β-cyclodextrin, and store the mother liquor and dregs in a separate container. The ratio of volatile oil to β-cyclodextrin is 1:14 (1ml of cinnamon volatile oil is wrapped with 14 grams of β-cyclodextrin by weight), stirred at 65°C for 4 hours at a speed of 1500 rpm, and set aside.

[0047] Take Scutellaria baicalensis and add water to decoct twice, add 14 times the amount (volume / weight of medicinal materials) of water for the first time, add 12 times the amount (volume / weight of medicinal materials) of water for the second time, decoct for 3 hours each time, filter, and combine the filtrates , concentrat...

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PUM

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Abstract

The invention relates to a pharmaceutical composition for the prevention and treatment of prostate gland hyperplasia prepared through extraction and isolation processes, which mainly comprises (by weight ratio) ootheca rubra 1-13 parts, and plantain seed 1-15 parts, baikal skullcap root 0.5-10 parts, Achyranthes bidentatae 0.5-7.5 parts, Cinnamomum cassia 0.5-5 parts, seed of cowherb 1-10 parts.

Description

technical field [0001] The invention belongs to a pharmaceutical composition for preventing and treating prostatic hyperplasia and a preparation method thereof, in particular to a pharmaceutical composition for preventing and treating prostatic hyperplasia derived from traditional Chinese medicine and an industrially applicable preparation method thereof. Background technique [0002] Benign prostate hyperplasia (BPH for short, the same below) is a disease in which the hyperplastic prostate compresses the prostatic urethra or affects the bladder and urethral opening, resulting in frequent urination, difficulty urinating, and even inability to discharge urine. It is a common disease in middle-aged and elderly men. , frequently-occurring disease. In recent years, Chinese medicine scholars have made a lot of useful explorations in the process of exploring the treatment of BPH with traditional Chinese medicine. Traditional Chinese medicine does not have the concept of BPH, and t...

Claims

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Application Information

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IPC IPC(8): A61K9/20A61K9/48A61K35/64A61P13/08
Inventor 林本忠段金廒陈彦石磊方志军
Owner JIANGSU PROVINCE INST OF TRADITIONAL CHINESE MEDICINE