Novel alanine transaminase enzyme and methods of use

An assay, protein technology, applied in the field of predicting and monitoring markers of tissue damage and/or dysfunction, capable of addressing issues such as unmentioned

Inactive Publication Date: 2005-07-06
北京昭衍新药研究中心股份有限公司
View PDF2 Cites 4 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But neither patent mentions a naturally occurring human ALT isozyme that could lead to improvements in current diagnostic assays for liver damage

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Novel alanine transaminase enzyme and methods of use
  • Novel alanine transaminase enzyme and methods of use
  • Novel alanine transaminase enzyme and methods of use

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0025] The present invention includes the nucleic acid and amino acid sequences of ALT2, the specific antibodies of ALT2 and ALT1 and the application of the above proteins, nucleic acids and antibodies to diagnose different diseases and conditions containing ALT2 tissues such as fatty liver and metabolic syndrome X, and for differential diagnosis of different Liver damage due to various causes, including fatty liver (hepatic steatosis), alcohol, trauma, infection, poisoning, and other causes of liver damage.

[0026] The present invention also includes ALT2 analogues and functional fragments, expression vectors containing ALT2 nucleic acid sequences and host cells containing ALT2 nucleic acid sequence expression vectors.

[0027] In this application, sequence analysis software such as the GCG sequence analysis software package of the University of Wisconsin or NCBI's BLAST programs are used to measure the degree of similarity of analogues. Such software determines the degree o...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

PropertyMeasurementUnit
molecular weightaaaaaaaaaa
Login to view more

Abstract

A novel alanine aminotransferase gene (ALT2) has been isolated from human tissues, and ALT2-specific nucleic acids, proteins and antibodies thereof have been described above. ALT2 is mainly expressed in liver, kidney, brain, muscle and adipose tissue. ALT2 can be used as a diagnosis of damage and disease of ALT2-producing tissues.

Description

[0001] related application [0002] This invention is funded by the National Institutes of Health Institute of Diabetes, Digestive and Kidney Diseases Fund (R21DK57835-01), and the government of the United States of America has certain rights in this invention. [0003] This application claims priority to US Patent Application 60 / 290,829, filed May 14, 2001, which is incorporated herein by reference. technical field [0004] The present invention relates to a novel isoenzyme of human alanine aminotransferase (ALT), ALT2, and its use as a marker for predicting and monitoring tissue damage and / or dysfunction. The present invention and its use detect ALT2 as a diagnosis involving tissue damage and / or dysfunction caused by various etiologies including, but not limited to, hepatitis, non-alcoholic hepatic steatosis (NASH), fatty liver, cirrhosis, drug-induced hepatitis And abnormalities in tissues such as muscle, brain, kidney and fat. Background technique [0005] Alanine amin...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/00C07H21/04C12N9/10C12N9/64C12N15/00C12Q1/68G01N33/53G01N33/537G01N33/543
CPCA61K38/00C12N9/1096
Inventor 龚大为艾伦·舒尔迪纳杨荣泽
Owner 北京昭衍新药研究中心股份有限公司
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap