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Oil-in-water emulsion composition

An emulsified composition and oil-in-water type technology, which can be used in drug combination, cosmetics, emulsion delivery, etc., and can solve the problems of alkoxy salicylic acid stability inspection, poor storage stability, separation or separation, etc. , to achieve the effect of good stability and usability, excellent whitening effect

Active Publication Date: 2005-07-13
SHISEIDO CO LTD
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] However, when alkoxysalicylic acid is blended into an oil-in-water emulsion composition, there is a problem that storage stability, especially temperature (high temperature and low temperature) stability is poor, and separation or separation is likely to occur over time.
[0005] In addition, although the present applicant has proposed an oil-in-water emulsified composition (Patent Document 2) that has improved usability and high-temperature stability by including an α-gel in the external phase, it does not contain an alkoxy group. Investigation and research on the stability of salicylic acid

Method used

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  • Oil-in-water emulsion composition
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  • Oil-in-water emulsion composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1～4

[0082] (Examples 1-4, Comparative Examples 1-4)

[0083] An oil-in-water emulsion composition having the compositions of Examples and Comparative Examples shown in Table 1 below was prepared and used as a sample, and evaluated for temporal stability and usability according to the following evaluation criteria. The combined results are shown in Table 1.

Embodiment 5～7、 comparative example 5～7

[0085] An oil-in-water emulsion composition having the compositions of Examples and Comparative Examples shown in Table 2 below was prepared and used as a sample, and evaluated for temporal stability and usability according to the following evaluation criteria. The combined results are shown in Table 2.

[0086] (preparation method)

[0087] In Tables 1 and 2, mix the water phase ingredients and oil phase ingredients in the recipe respectively, add the oil phase heated to 80°C to the water phase at 80°C, emulsify evenly with a homomixer, add and dissolve in water The pharmaceutical ingredients were stirred and cooled to room temperature to prepare an oil-in-water emulsified composition.

[0088] In addition, in Tables 1 and 2, the number of moles of "(C) component (*1) ", "(B) The number of moles of ingredients or surfactants (*1) "All represent the number of moles contained in 100 g of oil-in-water emulsion compositions.

[0089] In addition, the (C) component (mass %) re...

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Abstract

The present invention provides an oil-in-water emulsified composition that has good emulsification stability over time in a system containing alkoxysalicylic acids and is excellent in usability. This oil-in-water emulsified composition contains (A) alkoxy salicylic acid or its salt, (B) long-chain acyl sulfonate type anionic surfactant, (C) higher fatty alcohol, (D) water , and (E) oil component, and, (i) form a gel with (B) component, (C) component and (D) component, and the transition temperature of the formed gel is 60° C. or higher, (ii) form the above-mentioned The compounding quantity of the (B) component of a gel is 0.1 mass % or more but less than 1.0 mass % with respect to the whole oil-in-water emulsion composition, (iii) (B) component which forms the said gel and (C The molar ratio of the compounding amount of ) component is 1:3, (iv) contains excess (C) component or amphiphilic substance that does not participate in gel formation, and its compounding amount is relative to the total amount of the oil-in-water emulsion composition. 0.5 to 10% by mass.

Description

technical field [0001] The present invention relates to an oil-in-water emulsion composition mainly used as an external preparation for skin. More specifically, it relates to an oil-in-water emulsion composition which is excellent in whitening effect and excellent in temporal stability and usability. Background technique [0002] "Whitening", which means fair and beautiful skin, is one of the most important issues in skin external preparations, especially in cosmetics. [0003] In cosmetics for the purpose of "whitening", for example, vitamin C or its derivatives, arbutin and the like can be blended as whitening ingredients. In recent years, the search for whitening ingredients has become more and more active, and as one of the results, alkoxysalicylic acids have been proposed as ingredients excellent in whitening effects (Patent Document 1). [0004] However, when alkoxysalicylic acids are blended into an oil-in-water emulsion composition, there is a problem that storage ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/107A61K8/00A61K8/06A61K8/30A61K8/33A61K8/34A61K8/46A61K8/92A61K31/60A61P17/16A61Q19/02
Inventor 井上东彦渡边启
Owner SHISEIDO CO LTD