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Fatty acyl acetaldehyde transfusion preparation and its preparing method

A fatty acetaldehyde and aldehyde-based technology, which is applied in anti-inflammatory agents, pharmaceutical formulations, emulsion delivery, etc., can solve the problem of adding small doses of injections, which cannot solve the problem of the solubility of the active ingredient fatty acetaldehyde, Stability problems, pain problems, large doses, increased workload of medical staff, etc., to achieve stable and reliable results

Inactive Publication Date: 2005-08-03
KUNMING ZIJIAN BIOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But there are still many problems in existing Houttuynia cordata injection (active ingredient is also Houttuynia cordata), Houttuynia cordata sodium (1995 edition Chinese Pharmacopoeia) injection, new Houttuynia cordata injection, if can not be very Solve the solubility problems, stability problems, pain problems during injection, and large dose problems of the active ingredient fatty acetaldehyde, so that the production, sales and use of this series of products cannot meet the needs of the market
In addition, current patients generally have the problem of drug resistance. When using it, it is necessary to increase the dosage of a single dose, that is, increase the number of small-dose injections to achieve the effect of high-dose shock therapy, which will undoubtedly increase the workload of medical staff. , bringing many disadvantages to the rescue of critically ill patients

Method used

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  • Fatty acyl acetaldehyde transfusion preparation and its preparing method
  • Fatty acyl acetaldehyde transfusion preparation and its preparing method

Examples

Experimental program
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Effect test

Embodiment 1

[0046] The synthesis process of high houttuyniatin is as follows, the process principle:

[0047]

[0048] Raw material: levulinic acid 366g

[0049] Lauric acid (dodecanoic acid) 631g

[0050] Methanol 2500ml

[0051] Potassium hydroxide 27g

[0052] crafting process:

[0053] 1. Dissolve potassium hydroxide in methanol first, then add levulinic acid and lauric acid to dissolve;

[0054] 2. Put the obtained solution into the electrolytic cell, and conduct electrolysis with electricity, the control condition parameters are: current 3-30A, voltage 60-90V, time 56-126 hours;

[0055] 3. After the reaction, take out the reaction liquid, concentrate, recover methanol, pour out when yellow oil appears, acidify, wash with water, separate the oil, conduct vacuum distillation once, rectify once, and collect pentadecone-2;

[0056] 4. Take 100g of pentadecone-2, 55g of ethyl formate, and 600ml of anhydrous benzene, put them into a reflux reactor, add 15g of me...

Embodiment 2

[0061] Houttuyniatin Ordinary Infusion, formula:

[0062] Houttuyniatin 8g

[0063] Mannitol 3000g

[0064] Sodium chloride 100g

[0065] Preparation process: under the condition of grade 10,000, dissolve 3,000g of mannitol and 100g of sodium chloride in ~30,000ml of water for injection, and pay attention to completely dissolve it. Add houttuyfonate under stirring, stir until houttuyniatin is completely dissolved, add water for injection to dilute to 48000ml, adjust acidity and isotonicity, add water for injection to 50000ml. Filtration, the filtrate is treated with filter paper and 0.4μm filter membrane, and then filtered with a filter membrane below 0.2μm under the condition of 100 grades. The fine filtrate is sent to the packing machine, packed according to 50ml per bottle, covered with a lid, tied up, sent to a steam sterilizer for sterilization, taken out of the finished product, packaged, inspected, qualified, and finished. 1000 bottles of 8 mg houttuyonin general in...

Embodiment 3

[0067] Eight kinds of amino acid infusion of new houttuyniatin, formula (1000ml):

[0068] Neo Houttuyniatin 32mg L-Isoleucine 3.82g

[0069] L-Leucine 5.03g L-Lysine Acetate 4.52g

[0070] L-Methionine 2.34g L-Phenylalanine 5.65g

[0071] L-Threonine 2.78g L-Tryptophan 1.0g

[0072] L-Valine 3.98g Mannitol 70g

[0073] Preparation process: under the condition of 10,000 grade and nitrogen protection, first dissolve a small amount of L-tryptophan in ~20ml of water for injection, and pay attention to make it completely dissolved, and set aside; Dissolve in water for injection, and pay attention to make it completely dissolved, filter, and set aside; then dissolve other amino acids in an appropriate amount of water for injection ~ 500ml, add the above-mentioned dissolved tryptophan solution and new houttuyniatin solution, add mannitol and use Dilute with water for injection to the required volume ~800ml, add antioxidant, adjust isotonicity, add water for injection to the fina...

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Abstract

The present invention provides a kind of fatty acyl acetaldehyde transfusion preparation. The fatty acyl acetaldehyde transfusion preparation includes fatty acyl acetaldehyde as bioactive component and medicinal supplementary material, and features that each dose contains fatty acyl acetaldehyde in 8-100 mg, wherein fatty acyl acetaldehyde is R-COCH2CHO, with R being C8-C14 hydrocarbon compound. The present invention has the effects of clearing away heat and toxic material, eliminating pus, promoting diuresis and relieving stranguria, and has high curative effect, certain delayed releasing effect, no irritation and no toxic side effect.

Description

technical field [0001] The invention relates to a bioactive fatty acetaldehyde infusion solution capable of antibacterial and anti-inflammatory, improving immune function and providing energy and a preparation method thereof. Background technique [0002] In traditional Chinese medicine, there is a plant known as a magical plant antibiotic - Houttuynia cordata. It is the dry aboveground part of Houttuynia cordata Thunb. Have heat-clearing and toxic substances removing, eliminate carbuncle and expel pus, the effect of inducing diuresis and treating stranguria. Modern pharmacological studies have confirmed that Houttuynia cordata has anti-pathogenic microorganisms, anti-inflammation, anti-allergic and anti-asthma effects, can improve immune function, diuretic and so on. Clinically, it is often used to treat respiratory system, digestive system, urinary system, ENT, ophthalmology, surgical infection and other diseases. After research, it is found that the main active ingredi...

Claims

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Application Information

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IPC IPC(8): A61K9/107A61K31/121A61P11/00A61P13/00A61P29/00A61P31/00
Inventor 杨兆祥
Owner KUNMING ZIJIAN BIOTECH
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