Dihydromyricitrin fatty ester preparing process

A technology of dihydromyricetin and fatty acid esters, which is applied in the direction of organic chemistry and can solve the problems of dihydromyricetin insoluble in fat and limitations

Inactive Publication Date: 2005-09-28
SERICULTURE & AGRI FOOD RES INST GUANGDONG ACAD OF AGRI SCI
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  • Abstract
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Problems solved by technology

[0004] Publication numbers CN 1288747A, CN 1288892A, etc. have disclosed that the compound has the effects of treating hepatitis, protecting the liver, antibacterial and anti-inflammatory, analgesic, lowering blood fat, expectorant and enhancing immunity of the immune system; but dihydromyricetin cannot be dissolved in Lipid compound system, which limits its role

Method used

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  • Dihydromyricitrin fatty ester preparing process

Examples

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Embodiment 1

[0013] Take 2.00g of dihydromyricetin, dissolve (dilute) with 20ml of ethyl acetate, add 5g of potassium bicarbonate, heat to 40°C, add 1.2-10g of palmitoyl chloride dropwise within 30min, continue to keep warm for 1.5h and then filter, the filtrate Washed with water, concentrated under reduced pressure, recrystallized, and then dehydrated and dried to obtain dihydromyricetin palmitate.

[0014] Example 1

[0015] Take 10.00g of dihydromyricetin, dissolve (dilute) with 100ml of ethyl acetate, add 20g of potassium bicarbonate, heat to 80°C, add 10-20g of stearic acid dropwise within 60min, continue to keep warm for 3h and then filter, the filtrate is passed through Wash with water, concentrate under reduced pressure, recrystallize, and then dehydrate and dry to obtain dihydromyricetin stearate.

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Abstract

The present invention provides the preparation process of dihydromyricitrin fatty ester capable of being dissolved in lipid compound system. Dihydromyricitrin and / or dihydromyricitrin composition as material is dissolved and / or diluted in inert organic solvent, and in the presence of alkali catalyst and / or metal catalyst, fatty acyl halide is dropped slowly into the inert solution of dihydromyricitrin and / or dihydromyricitrin composition for reaction at 25-120 deg.c to obtain dihydromyricitrin fatty ester. The prepared dihydromyricitrin fatty ester is water soluble and soluble in various lipid compound system.

Description

technical field [0001] The invention relates to a preparation method of dihydromyricetin fatty acid ester. Background technique [0002] Dihydromyricetin (ampelopsin / grossedentata) is a known compound, document Walter Karrarr, Birkhauser Verlag und Stuttgart (1958), P.652, NO: 1640 announced its structural formula as: [0003] [0004] Publication numbers CN 1288747A, CN 1288892A, etc. have disclosed that the compound has the effects of treating hepatitis, protecting the liver, antibacterial and anti-inflammatory, analgesic, lowering blood fat, expectorant and enhancing immunity of the immune system; but dihydromyricetin cannot be dissolved in The lipid compound system limits its function. Therefore, it needs to be modified. Contents of the invention [0005] The purpose of the present invention is to overcome the shortcoming in the application of dihydromyricetin at present, and provide a kind of preparation method of d...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D311/32
Inventor 张友胜肖更生陈卫东邹宇晓吴继军李升锋徐玉娟陈智毅刘学铭
Owner SERICULTURE & AGRI FOOD RES INST GUANGDONG ACAD OF AGRI SCI
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