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Dispersible tablet of naked flower beautyberry leaf and its preparation process

A technology of nude flower purple beads and dispersible tablets, which is applied in the direction of medical preparations containing active ingredients, pharmaceutical formulas, pill delivery, etc. It can solve the problems of low solubility, slow dissolution speed, and influence of drug absorption, etc., and achieve high bioavailability Effect

Inactive Publication Date: 2005-11-23
刘小清
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, for ordinary tablets and capsules, there are generally disadvantages of slow dissolution rate and low solubility, which have a certain impact on the absorption of drugs.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] Embodiment 1: 3.2 parts of Nadihuazizhu extract powder, 2 parts of cross-linked polyvinylpyrrolidone xl-10, 2 parts of microcrystalline cellulose, and 0.4 parts of micronized silica gel.

[0018] Preparation:

[0019] (1) Medicinal material extraction: take the naked flower purple pearl, add water to decoct twice, the first time for 2 hours, the second time for 1 hour, combine the decoction, filter, and concentrate the filtrate into a thick paste for later use;

[0020] (2) Ingredients: add half of the prescription amount of microcrystalline cellulose and half of cross-linked polyvinylpyrrolidone xl-10;

[0021] (3) Granulation: the mixture is granulated, passed through a 18-mesh sieve, and dried for subsequent use;

[0022] (4) Ingredients: add the remaining microcrystalline cellulose, cross-linked polyvinylpyrrolidone xl-10, and micropowder silica gel and mix well for later use;

[0023] (5) Tablet compression: compress the above homogeneous mixture into tablets.

Embodiment 2

[0024] Example 2: 2 parts of Nadihuazizhu extract powder, 1 part of crosslinked polyvinylpyrrolidone xl-10, 1 part of microcrystalline cellulose, and 0.3 part of micronized silica gel.

[0025] Preparation:

[0026] (1) Medicinal material extraction: take the naked flower purple pearl, add water to decoct twice, the first time for 1 hour, the second time for 5 hours, combine the decoction, filter, and concentrate the filtrate into a thick paste for later use;

[0027] (2) Ingredients: add half of the prescription amount of microcrystalline cellulose and half of cross-linked polyvinylpyrrolidone xl-10;

[0028] (3) Granulation: the above mixture is granulated (over 18 meshes), and dried for subsequent use;

[0029] (4) Ingredients: add the remaining microcrystalline cellulose, cross-linked polyvinylpyrrolidone xl-10, and micropowder silica gel and mix well for later use;

[0030] (5) Tablet compression: compress the above homogeneous mixture into tablets.

Embodiment 3

[0031] Embodiment 3: Embodiment 1: 3.6 parts of Nadihua Zizhu extract powder, 3 parts of sodium starch glycolate, 3 parts of microcrystalline cellulose, 0.36 part of micropowder silica gel.

[0032] Preparation:

[0033] (1) Medicinal material extraction: take the naked flower purple pearl, add water to decoct twice, the first time is 2 hours, the second time is 3 hours, combine the decoction, filter, and the filtrate is concentrated into a thick paste for later use;

[0034] (2) Ingredients: add half of the prescription amount of microcrystalline cellulose and sodium carboxymethyl starch;

[0035] (3) Granulation: the above mixture is granulated (over 18 meshes), and dried for subsequent use;

[0036] (4) Ingredients: add remaining microcrystalline cellulose, sodium carboxymethyl starch, micropowder silica gel and mix well for later use;

[0037] (5) Tablet compression: compress the above homogeneous mixture into tablets.

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PUM

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Abstract

The invention relates to a dispersible tablet of naked flower beautyberry leaf and its preparation process, wherein the dispersible tablet comprises the following constituents (by weight ratio), nudiflower beautyberry leaf concrete powder 1-10 parts, crumbling agent 1-10 parts, thinning agent 1-10 parts, other auxiliary materials 0.04-1 part. The preparing process comprises the following steps, (1) extracting medicinal materials, charging water into nudiflower beautyberry leaf, grilling two times, merging the grilling liquid, filtrating, concentrating the filtrate into thick grease, (2) a dispensing procedure comprising, charging thinning agent and crumbling agent half of the prescription amount, (3) a granulation procedure comprising, palletizing the mixture and passing through 20-12 mesh sieve, drying for later use, (4) a dispensing procedure comprising, charging the residual thinning agent and crumbling agent, mixing with other auxiliary materials, (5) tabletting the mixture.

Description

technical field [0001] The invention relates to a nude flower dispersible tablet and a preparation method thereof. Background technique [0002] Naked flower purple pearl is a traditional Chinese medicinal material, which has anti-inflammatory, detoxification, astringent, and hemostatic effects. In the current upper respiratory tract infection market with a large amount of drugs, but the share of safe and effective traditional Chinese medicine varieties is still small, it is very important to develop the pharmacological effects of Nadihuazizhu. The currently developed nudehuazizhu medicaments mainly include nudehuazizhu tablets and nudihuazizhu capsules, which are used for inflammation caused by bacterial infection, acute infectious hepatitis, respiratory tract and gastrointestinal bleeding and other diseases. However, for ordinary tablets and capsules, there are generally the disadvantages of slow dissolution rate and low solubility, which have a certain impact on the abso...

Claims

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Application Information

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Patent Type & Authority Applications(China)
Inventor 刘小清
Owner 刘小清
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