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Antibiotic composition for injection

An antibacterial composition and technology for injection, which is applied in the field of antibacterial composition for injection containing ticarcillin, can solve the problems of poor physical and chemical stability of potassium clavulanate, difficulties in preparation production, transportation and storage, etc., and achieve good stability of finished products , easy to produce, and expand the effect of antibacterial spectrum

Inactive Publication Date: 2005-12-14
SHANDONG BESTCOMM PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] However, the physical and chemical stability of potassium clavulanate is poor. The Chinese Pharmacopoeia 2000 stipulates that its raw materials should be tightly sealed and stored in a dry place below -20°C.
This creates difficulties in the production, transportation and storage of formulations

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0016] The present invention will be further described through examples below, and these descriptions are not intended to further limit the content of the present invention. Those skilled in the art should understand that equivalent replacements or corresponding improvements made to the contents of the present invention still fall within the protection scope of the present invention.

[0017] The antimicrobial composition of ticarcillin sodium / tazobactam sodium for injection was determined by agar double dilution method (based on ticarcillin and tazobactam respectively, the weight ratio was 1:1, 2:1, 4:1 , 8:1, 16:1, 32:1) in vitro antibacterial effect on 153 clinical isolates of pathogenic bacteria.

[0018] Results: For the tested strains susceptible to ticarcillin alone, there was no significant difference in in vitro antibacterial activity between single use and different ratios of ticarcillin / tazobactam. Ticarcillin alone and ticarcillin / tazobactam 1:1, 2:1, 4:1, 8:1, 16...

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PUM

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Abstract

The present invention relates to antibiotic composition for injection, and is especially one kind of antibiotic composition for injection containing ticarcillin. The present invention solves the technological problem in providing antibiotic composition for injection with high stability, easy production, easy transportation and easy storing. The antibiotic composition for injection contains ticarcillin or its pharmaceutical salt and tazobactam or its pharmaceutical salt in the weight ratio of 1-32 to 1 accounting in ticarcillin and tazobactam separately. Compared with ticarcillin, the antibiotic composition for injection has higher antibiotic activity and expended antibiotic spectrum.

Description

technical field [0001] The invention relates to an antibacterial composition for injection, in particular to an antibacterial composition for injection containing ticarcillin. technical background [0002] Ticarcillin (ticarcillin) is a semi-synthetic penicillin injection for injection, which is a thienyl carboxypenicillin. Its antibacterial spectrum and pharmacological properties are similar to those of carboxybenicillin. Ticarcillin is a bactericidal drug that affects the synthesis of bacterial cell walls by interfering with mucopeptide cross-linking, resulting in defects or weakness in cell walls, deformed bacteria, and rapid dissolution and death, thereby achieving antibacterial effects. The antibacterial spectrum of ticarcillin is similar to that of carboxybenicillin, and its antibacterial effect on Gram-positive bacteria is lower than that of penicillin G; the antibacterial effect on Gram-negative bacteria is several times stronger than that of carboxybenicillin, and ...

Claims

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Application Information

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IPC IPC(8): A61K31/431
Inventor 孟凡清
Owner SHANDONG BESTCOMM PHARMA CO LTD