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Devices and methods for programmable microscale manipulation of fluids

A fluidic and fluidic technology, applied in the field of microfluidic circuits, can solve problems such as lack of attractiveness and achieve low-cost effects

Inactive Publication Date: 2006-03-08
SPINX INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Valve regulation methods that rely on reusable valves are unattractive in most microfluidic applications

Method used

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  • Devices and methods for programmable microscale manipulation of fluids
  • Devices and methods for programmable microscale manipulation of fluids
  • Devices and methods for programmable microscale manipulation of fluids

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0221] Such as Figure 7 As shown, focused optical feedback is performed according to the invention to assess correct positioning on material layer 701 . go to Figure 7 , the optical feedback uses simple glass 702 (about 0.199 mm thick) that intercepts a small percentage of the light reflected from the material layer 701 (through the same optical system used for light incident on the substrate). The light from material layer 701 is imaged on CCD 706 by a 48 mm focal length objective lens. The CCD 706 records the actual shape of the laser spot on the material layer 701 and is even able to image the surface of the material layer and eg beads floating in the fluid near the material layer.

[0222] It is conceivable within the scope of the invention to implement optical feedback using astigmatic focusing. It is further conceivable within the scope of the present invention to zoom in or out of the laser node image depending on the focal length ratio of the device (currently 3.1...

Embodiment 2

[0229] The performance of the optical device of the present invention can be characterized by the following examples. The optics are configured such that the volume of the CD lens and all of its exit apertures sums to an energy of 16 μJ post-beam delivered in 10 μs corresponding to 1.6 W of optical power. As expected, the original 6.2W laser diode power can be reduced due to alignment, matching and reflections in the optics.

[0230] When an 8 μm layer of Epolight 2057-loaded PMMA material made by Microchem was placed at the focal point of the CD lens and the first shot was made, only about 6.7 μJ was emitted from the substrate onto the thermometer located behind the material layer. Neglecting the reflection, it is expected to be about 4%, so the remaining 8.4 microjoules are deposited in the sample. For reference, if energy is deposited uniformly in a sample of 1 microliter of water, its temperature rises only by about 0.0018°C. However, this energy is sufficient to melt th...

Embodiment 3

[0234] The performance of the laser of the present invention can be further understood with reference to the following examples. The laser shot source used is an OSRAM SPL PL_3 diode with nanostack technology. Nanostacking consists in the "vertical" or epitaxial integration of many discrete emitters on a semiconductor chip, which yields two to three times the maximum power. The particular diode exhibited a gap of 200 x 10 microns from the three stacked emitters, which achieved an optical output of about 75 W when confined to a pulse width of 100 ns. The diodes were pulsed using a DEI PCX 7410 diode laser driver manufactured by Directed Energy Inc. capable of covering the 20 ns to 1 μs range in CW at 1OA and 5A. To reach a range beyond 10A, a DEI PCO 7120 hybrid OEM driver is used. Pulse voltage and current were monitored with a Tektroix TDS2014 to recreate power across the diode and its optical output was extrapolated on the basis of the diode specification.

[0235] Concen...

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Abstract

The present invention is directed generally to devices and methods for controlling fluid flow in meso-scale fluidic components in a programmable manner. Specifically, the present invention is directed to an apparatus and method for placing two microfluidic components in fluid communication at an arbitrary position and time, both of which are externally defined. The inventive apparatus uses electromagnetic radiation to perforate a material layer having selected adsorptive properties. The perforation of the material layer allows the fluid communication between microfluidic components. Other aspects of this invention include an apparatus and method to perform volumetric quantitation of fluids, an apparatus to program arbitrary connections between a set of input capillaries and a set of output capillaries, and a method to transport fluid in centripetal device from a larger to a smaller radius. In addition, the present invention also is directed to a method to determine the radial and polar position of a pickup in the reference frame of a rotating device.

Description

[0001] Cross References to Related Applications [0002] This application claims priority to US Provisional Application No. 60 / 430,792, entitled "Apparatus and Method for Programmable Microcontrol of Fluids," filed December 4, 2002, the entire contents of which are incorporated herein by reference. technical field [0003] The present invention relates to the field of microfluidic circuits for chemical, biological and chemical processes or reactions. More specifically, the present invention discloses devices and methods for controlling fluid flow in a microstructure in a programmable manner. Background technique [0004] In recent years, the pharmaceutical, bioprocessing, chemical and related industries have increasingly adopted tiny chamber and channel structures for various reactions and analyses. The advantages of these structures include miniaturization, savings in space and reagent costs, and enabling one to perform a large number of reactions in parallel or in series ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): F16K17/14G01N9/30B01F11/00B01F13/00B01F13/08B01F15/02B01L3/00B81C99/00F16K17/40F16K99/00G01N21/01G01N35/00
CPCB81C1/00119B01F15/0205F16K99/0001G01N21/01B01L2400/0683B81C2201/019F16K99/004B01L2300/0864B81B2201/058F16K99/003B01F13/0809F16K2099/0084Y10T137/1632B01F13/0059F16K2099/0073B01L2400/0409B01L2300/0654Y10T137/1624B01L3/502738G01N35/00069G01N2035/00247F16K2099/008G01N2001/2886F16K99/0034Y10T436/2575B01L2300/0861B01L2300/0806B01F11/0002B01L2300/0803B01L2300/0887B01L2400/0677B01L3/50273B01L3/502715B01F31/10B01F33/30B01F33/451B01F35/713
Inventor 皮耶罗·祖凯利巴尔特·范德维维尔
Owner SPINX INC
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