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Angelica and south date soft capsule and preparation method thereof

A technology of soft capsules and Angelica, applied in the field of Angelica Nanzao Soft Capsules and its preparation, can solve problems such as unfavorable consumption by diabetic patients, stability of preparation quality, adverse effects of long-term storage, and reduction of effective components, etc., and achieve the production process Improve the effect of reasonableness, quality and curative effect guarantee, and dosage reduction

Inactive Publication Date: 2006-05-03
CHONGQING PHARMA RES INST +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to the addition of a large amount of sucrose, the dosage is large, 10-20 grams each time, and it is inconvenient to take, especially unfavorable for diabetics.
The volatile oil in angelica has analgesic effect. According to the traditional preparation method and dosage form, the volatile oil components are not collected and dissipated, and the effective components are reduced, which affects its analgesic effect and curative effect
In addition, the extracts of angelica, jujube and Polygonum multiflorum have strong hygroscopicity, which has a major adverse effect on the quality stability and long-term storage of the preparation

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0041] Angelica, jujube, and Polygonum multiflorum are fed according to the best formula.

[0042] 1. Take 1500 grams of Angelica sinensis, crush it into a coarse powder, add 10 times the amount of water to decoct for 6 hours, and distill and collect the volatile oil at the same time. After that, filter the decoction, and concentrate the filtrate under reduced pressure at 60 ° C to 90 ° C to the medicinal material: concentrated solution=1:1 (w / w), add an equivalent amount of ethanol to precipitate, filter to obtain the filtrate for subsequent use; add 8 times the amount of 70% ethanol to the medicinal residues, reflux for 2 hours, filter to obtain the filtrate; 6 times the amount of 70% ethanol, reflux for 1 hour, and filter to obtain the filtrate. The filtrates were combined, ethanol was recovered under reduced pressure at 60°C to 90°C, and concentrated into a thick paste for later use.

[0043] 2. Take 700 grams of Chinese jujube and 175 grams of Polygonum multiflorum crush...

Embodiment 2

[0047] Angelica, jujube, and Polygonum multiflorum are selected according to the best formula.

[0048] 1. Take 1500 grams of Angelica sinensis, crush it into a coarse powder, add 8 times the amount of 70% ethanol, soak it twice at room temperature for 24 hours each time, combine the soaking liquid, filter, and concentrate the filtrate into a thick paste.

[0049] 2. Take 700 grams of Chinese jujube and 175 grams of Polygonum multiflorum crushed into coarse powder, add 10 times the amount of water to decoct for 2 hours, and filter to obtain the filtrate; add 8 times the amount of water to the dregs and decoct for 2 hours, filter, and use the filtrate twice Merge and concentrate under reduced pressure until medicinal material: concentrated solution=1:1 (w / w), add an equivalent amount of ethanol to precipitate, filter, and the filtrate reclaims ethanol under reduced pressure at 60°C to 90°C, concentrates into a thick paste (50 ℃, 1.20±0.5 g / ml) for later use.

[0050] Combine the...

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PUM

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Abstract

The invention relates to an angelica and south date soft capsule and preparation method, wherein the capsule is prepared from (by weight ratio) Chinese angelica root 1200-1800g, Chinese date 560-840g and fleece-flower root 140-210g through mixing with vegetable oil and suspension adjuvant, and pressing into soft capsules.

Description

Technical field: [0001] The invention relates to a medicine and a preparation method thereof, in particular to an angelica nanzao soft capsule and a preparation method thereof. Background technique: [0002] Danggui Nanzao Granules is a variety of traditional Chinese medicine preparations recorded in the "Drug Standards of the Ministry of Health of the People's Republic of China", and the number is WS 3 -2314-97. [0003] Danggui Nanzao Granule is a commonly used medicine in gynecology, which has the effects of nourishing blood, promoting blood circulation, regulating menstruation and relieving pain. For blood deficiency, irregular menstruation, dysmenorrhea, headache, vomiting, insomnia, hypochondriac pain and habitual constipation caused by menstrual syndrome. [0004] For a long time, this prescription has always been in the form of granules. The traditional preparation method of this prescription is: soaking Angelica sinensis twice with 70% ethanol for 24 hours each ti...

Claims

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Application Information

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IPC IPC(8): A61K36/725A61K9/48A61P15/00
Inventor 唐文彦文慧英
Owner CHONGQING PHARMA RES INST
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