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Nimodipine soft capsule and its prepn

A technology for nimodipine and soft capsules, applied in the field of nimodipine sustained-release soft capsules and its preparation, can solve the problems of low bioavailability, large blood concentration fluctuations, and many times of taking, and achieve the effect of simple preparation

Inactive Publication Date: 2006-05-17
CHINA PHARM UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

This patented method for making an oral solid dosage medicine called nifedopidium allows it to be released slowly over time without being absorbed into blood vessels like stomachs. It achieves this through adding gelatin agents based on normal soft capsular materials that contain other ingredients such as polysaccharides (polymers) and sugars.

Problems solved by technology

Technologies for developing new medicines called nitrendipide that specifically target certain areas involved in cell death processes during stroke/ischemia were described earlier in previous researchers' publications. However, these existing methods had drawbacks like potential side effects due to their high concentration required for effective treatment. To address those issues, some companies proposed different ways to deliver them through controlled release systems.

Method used

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  • Nimodipine soft capsule and its prepn
  • Nimodipine soft capsule and its prepn

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0064] Preparation of contents: Take 400g of nimodipine, 3000g of PEG400, 1000g of PEG 600, and 100g of Tween 80 in a liquid mixing tank and heat and stir through interlayer steam until all nimodipine is dissolved to obtain liquid A. Take 20g of sodium alginate and 20g of pectin, dissolve them in 1000g of water, swell for half an hour, heat and stir to dissolve to obtain liquid B, add liquid A to liquid B, and mix well to obtain the content solution.

[0065] Capsule material preparation: Weigh 3500g water, 1155g glycerin, 3500g gelatin, 20.5g titanium dioxide, stir into uniform particles, add 75g 20% ​​paraben ethanol solution and 63g calcium chloride to carry out sol.

[0066] Pressed pills: Pressed on a soft capsule machine, and then shaped, washed and dried.

Embodiment 2

[0068] Contents preparation: take 20g sodium alginate, 10g gum arabic and 15g carrageenan, dissolve them in 800g water, swell for half an hour, heat and stir to dissolve; add 3200g PEG400 and 400g nimodipine in sequence and pass through the interlayer steam in the liquid preparation tank Heat and stir until a homogeneous mixture is formed, pass through a high-pressure milk homogenizer several times, and keep warm for later use.

[0069] Capsule material preparation: Weigh 3250g water, 1400g glycerin, 3500g gelatin, 16.5g titanium dioxide, stir into uniform particles, add 52.5g 20% ​​paraben ethanol solution and 94.5g calcium tartrate to carry out sol.

[0070] Pressed pills: Pressed on a soft capsule machine, and then shaped, washed and dried.

Embodiment 3

[0072] Contents preparation: Take 30g pectin and 10g gum arabic, dissolve them in 1200g water, swell for half an hour, heat and stir to dissolve; add 4000g PEG400 and 400g nimodipine in sequence, heat and stir through interlayer steam in the liquid mixing tank until a uniform mixture is formed , through a high-pressure milk homogenizer several times, and keep warm for later use.

[0073] Capsule material preparation: Weigh 3500g water, 1750g glycerin, 3500g gelatin, 87.5g iron oxide, stir into uniform granules, add 35g 20% ​​paraben ethanol solution, 120g sodium citrate and 31.5g calcium chloride to carry out sol.

[0074] Pressed pills: Pressed on a soft capsule machine, and then shaped, washed and dried.

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Abstract

The present invention relates to the field of medicine preparation, and is especially delayed releasing nimodipine soft capsule and its preparation process. By means of adding gelatinizer into the soft capsule material and adding natural high molecular compound into the capsule content, the present invention forms skeleton structure in the soft capsule to reach the aim of delayed release.

Description

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Claims

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Application Information

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Owner CHINA PHARM UNIV
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