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Capillary stop

A membrane and inlet technology, used in instruments, laboratory utensils, analytical materials, etc., can solve problems such as low conductivity and unclear current, and achieve the effect of reducing inherent problems

Active Publication Date: 2006-05-17
SOPHION BIOSCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the researchers are limited by their work, that is, the seal resistance (10-50MΩ) between the glass of the pipette and the diaphragm is much smaller than the resistance of the channel (10GΩ)
The electrical noise caused by this seal is the opposite of the resistance, so that it is large enough that the current flowing through the ion channel is indistinct, and its conductivity is less than that of the acetylcholine channel

Method used

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Embodiment Construction

[0075] see Figure 4 , the microfluidic system according to the invention is generally indicated by reference numeral 40 . The system is especially suitable for use with an external pump. The system 40 comprises a measuring device 1 and a pump 2, which in this embodiment is an external gas pressure pump. Measuring device 1 and pump 2 communicate with each other via a fluid channel 4 . According to the invention, the system 40 also includes a membrane 3 . The presence of the membrane 3 means that liquid can be introduced through the membrane 3, but when the filling process is complete, the membrane 3 closes the inlet to the system. This is required to ensure proper operation of the pump, otherwise it may short circuit.

[0076] In some cases, the gas flow resistance of the pump 2 and the measuring device 1 is large compared to the volume of the interconnecting channels 4, so that the filling process takes too long.

[0077] A second embodiment of the system according to th...

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Abstract

A microfluidics system comprising a channel having an inlet (32) and an outlet (38); a first membrane (31) positioned between the inlet (32) and outlet (38) and comprising an aperture having a radius within the range 0.1 to 50 μm, the inlet (32) and the outlet (38) being in hydraulic communication with one another, such that a fluid can move along the channel from the inlet to the outlet.

Description

technical field [0001] The present invention relates to a system having one or more fluid channels of submillimeter size. This system is used in chemistry, biochemistry, molecular cell biology, and is often referred to as a microfluidic system. Background technique [0002] The system involved in the present invention can be used to monitor the electrophysiological properties of plasma channels in plasma channels including lipid membrane structures, such as cellular structures, wherein the cell membranes form a surrounding measurement structure by establishing an electrophysiological measurement structure The high resistance closure of the electrodes makes it possible to measure and monitor the current flowing through the cell membrane. The system can form part of an instrument for performing the patch clamp technique, which is used in the study of, for example, ion transport channels and biological membranes. [0003] The general concept of electrical insulation of patch ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N33/487B01L3/00F04B19/00F15C5/00F16K99/00
CPCB01L3/502723B01L3/50273B01L3/502738B01L2200/12B01L2400/0487B01L2400/0688F04B19/006F16K99/0001F16K99/0015F16K99/0059F16K2099/0074F16K2099/0084
Inventor R·塔伯里斯基J·库钦斯基
Owner SOPHION BIOSCI