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Novel use of medicine composition contg. red-rooted salvia

A composition and drug technology, applied in the field of medicine, can solve problems such as multiple organ damage

Active Publication Date: 2006-06-14
TIANJIN TASLY PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] At present, the pharmaceutical composition composed of salvia miltiorrhiza, notoginseng, and borneol has been studied in the treatment of hypertension, hyperlipidemia, atherosclerosis, diabetes, etc., but the preparation of the pharmaceutical composition for the treatment of multiple organ damage caused by metabolic syndrome The application in medicine has not been reported yet

Method used

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  • Novel use of medicine composition contg. red-rooted salvia
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  • Novel use of medicine composition contg. red-rooted salvia

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0224] Take 450g of salvia miltiorrhiza, 141g of notoginseng, and 8g of borneol for later use;

[0225] The above three flavors and Salvia miltiorrhiza were extracted three times, for the first time, add ethanol to reflux for 1.5 hours, filter, recover ethanol from the filtrate, and concentrate to a relative density of 1.30 (55-60°C); for the second time, add 50% ethanol to reflux for 1.5 hours, filter; Add water three times to reflux for 2 hours, filter, combine the second and third filtrates, recover ethanol, concentrate to a relative density of 1.40 (55-60°C), combine with the first concentrated solution, and mix well to make a relative density of 1.35 ~1.39 (55°C) clear paste. Grind notoginseng into fine powder, mix well with salvia miltiorrhiza clear paste, dry to make granules, grind borneol into fine powder, mix with the above granules, press into 1000 pieces, or coat with sugar or film.

Embodiment 2

[0227] Take 215g of salvia miltiorrhiza extract, 141g of notoginseng, and 8g of borneol for later use;

[0228] The above three flavors and Salvia miltiorrhiza were extracted three times, for the first time, add ethanol to reflux for 1.5 hours, filter, recover ethanol from the filtrate, and concentrate to a relative density of 1.30 (55-60°C); for the second time, add 50% ethanol to reflux for 1.5 hours, filter; Add water three times to reflux for 2 hours, filter, combine the second and third filtrates, recover ethanol, concentrate to a relative density of 1.40 (55-60°C), combine with the first concentrated solution, and mix well to make a relative density of 1.35 ~ 1.39 (55 ~ 60 ℃) clear ointment. Grind notoginseng into fine powder, mix well with salvia miltiorrhiza clear paste, dry, and make granules, grind borneol into fine powder, mix with the above granules, press into 1000 pieces, or coat with sugar.

Embodiment 3

[0230] Take 450g of salvia miltiorrhiza, 141g of notoginseng, 8g of borneol, and 40g of beta cyclodextrin for later use;

[0231]For the above three medicinal materials, take Panax notoginseng and grind them into fine powder, set aside, add borneol to appropriate amount of ethanol to dissolve, take another beta cyclodextrin, add water, put it in a constant temperature water bath at 55°C, stir to dissolve, add the ethanol solution of borneol dropwise while stirring , continue to keep warm for 30 minutes under constant stirring, take it out, refrigerate, filter with suction, and dry the filter residue at 40°C for later use; take Salvia miltiorrhiza for three extractions, add ethanol for the first reflux extraction for 1.5 hours, filter, and concentrate the filtrate to a relative density of 1.30 (55 ~ 60 ℃) thick paste; add 50% ethanol for the second time to reflux and extract for 1.5 hours, filter; add water for the third time to reflux and extract for 2 hours, combine the second...

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Abstract

An application of the Chinese medicine prepared from red sage root, notoginseng and borneol in preparing the medicines for treating multi-organ injury caused by metabolic syndrome is disclosed.

Description

technical field [0001] The invention belongs to the field of medicine, and in particular relates to a new application of a medicinal composition containing salvia miltiorrhiza. Background technique [0002] Metabolic syndrome (Metabolic syndrome MS), also known as insulin resistance syndrome, is proposed by the American Cholesterol Education Committee in ATPIII and its diagnostic criteria. Clinical syndrome, the combination of insulin resistance, central obesity, impaired glucose tolerance or diabetes, hypertension, dyslipidemia and other diseases is collectively referred to as "metabolic syndrome" or "insulin resistance syndrome". The components of metabolic syndrome include: ① insulin resistance; ② hyperinsulinemia; ③ central (visceral) obesity; ④ elevated systolic and diastolic blood pressure; ⑤ abnormal lipid metabolism: elevated triglycerides, low HDL-C , small and dense LDL-C (type B) increased; ⑥ procoagulant state: increased plasma fibrinog...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/537A61K9/00A61K31/045A61P1/16A61P13/12
Inventor 闫希军吴廼峰郭治昕叶正良郑军张雷赵娜
Owner TIANJIN TASLY PHARMA CO LTD
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