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New use of tribulus terrestris extraction

A technology of Tribulus terrestris and extract, applied in the field of Tribulus terrestris extract, can solve problems such as no depression, and achieve the effect of improving depression state

Inactive Publication Date: 2006-09-13
SHANGHAI INST OF PHARMA IND
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But so far there is no report about the treatment of depression with Tribulus terrestris extract

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0011] The preparation of embodiment 1 Tribulus terrestris crude extract

[0012] Take 1 kg of the fruit of Tribulus terrestris as the raw material, reflux with five times of water to extract 3 times, each time for 1 hour, and the extract is spray-dried to obtain the crude extract of Tribulus terrestris. After determination, the crude extract of Tribulus terrestris contains 20% of total saponins (vanillin-perchloric acid method), 2% of polysaccharides and 1% of total flavonoids.

Embodiment 2

[0013] The preparation of embodiment 2 Tribulus terrestris total saponins

[0014] Take 1 kg of the raw material Tribulus terrestris, extract 3 times with eight times the amount of 75% ethanol under reflux, each time for 2.5 hours, combine the extracts, filter, place the filtrate in a cool place (temperature less than 10°C) for 12 hours, and centrifuge at 4000 rpm for 5 minutes Finally, take the supernatant, recover ethanol, concentrate to dry extract, dissolve into a solution with water and pass through a macroporous adsorption resin column (HPD100). After being applied to the column, wash with water until colorless, then wash with 30% ethanol until colorless, then elute with 70% ethanol, collect the eluate, recover the ethanol until it has no alcohol smell, spray dry it into a dry powder, and obtain the thorn The total saponins of Tribulus terrestris have a purity of 60%.

Embodiment 3

[0015] The preparation of embodiment 3 tribulus terrestris total flavonoids

[0016] Tribulus terrestris fruit 1kg, reflux extraction with 5 times the amount of water for 3 times, precipitate with ethanol, filter the precipitate, put the filtrate on a polyamide column, elute with water until colorless, then elute with acetone, collect the acetone eluate, Evaporate the acetone and dry to obtain the total flavonoids of the fruit of Tribulus terrestris. Content determination refers to the above-mentioned literature (Shiqin et al. Determination of 3 kinds of hydrolyzed flavonoid aglycones in Tribulus terrestris by reversed-phase high performance liquid chromatography. Drug Analysis Impurities; 1999, 19(2): 75-78 and Wu Qiongshi et al. Tribulus terrestris Determination of the content of total flavonoids in grass. Journal of Guangdong Pharmaceutical University; 1998, 14(4): 273-275), and its purity was determined to be 52%.

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Abstract

An application of the extract of puncturevine caltrop fruit in preparing the medicine, health-care products, or food for preventing and treating depression is disclosed.

Description

technical field [0001] The invention relates to a new application of the extract of Tribulus terrestris. Background technique [0002] The traditional Chinese medicine Tribulus terrestris is the dry mature fruit of Tribulus terrestris (Tritulus terrestris), a plant of the family Zygophyllaceae and the genus Tribulus. Pungent in nature and flavor, bitter, slightly warm, slightly poisonous, enters the liver and lung meridians, has the effects of dispersing wind, improving eyesight, lowering qi, promoting blood circulation, tonifying kidney and replenishing essence. Tribulus terrestris has a long history of medicinal use among Chinese folks. "Shen Nong's Materia Medica" listed "Tribulus terrestris" as a top-grade medicine, saying that it "maintains bad blood, breaks accumulation of crux, sore throat, breast difficulty, long-term use to grow muscles, and improve eyesight." , light body ". The Chinese Pharmacopoeia records its function as "calming the liver and relieving depres...

Claims

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Application Information

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IPC IPC(8): A61K36/185A61P25/24A23L1/30A61K131/00A23L33/105
Inventor 李明奉建芳
Owner SHANGHAI INST OF PHARMA IND
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