Application of salvianolic acid B in preparing medication for preventing tumorigenesis

A salvianolic acid and drug technology, applied in the field of medicine, can solve the problems of tissue cell damage, inability to prevent tumors, inability to take long-term medication, etc.

Inactive Publication Date: 2006-12-06
上海天甲生物医药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] Because drugs that usually have a strong killing effect on tumor cells can also cause damage to normal tissue cells, they cannot be used for a long time, and there is no drug that can completely

Method used

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  • Application of salvianolic acid B in preparing medication for preventing tumorigenesis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0058] Experimental observation on the preventive effect of salvianolic acid B and its magnesium salt on rat prostate cancer

[0059] 1. Experimental materials

[0060] (1) Experimental animals: F344 male rats, 5 weeks old, weighing about 90 grams;

[0061] (2) Prostate cancer chemical inducer: 3,2'-dimethyl-4-aminobiphenyl (DMAB) (purchased from Nard Research Institute, Japan);

[0062] (3) Experimental drug: salvianolic acid B, magnesium salt of salvianolic acid B;

[0063] 2. Experimental grouping: The experimental animals are divided into 10 groups.

[0064] (1) Blank control group (normal diet, no DMAB chemical induction): 1 group, 6 animals / group;

[0065] (2) Salvianolic acid B control group (salvianolic acid B mixed feed, without DMAB chemical induction): 1 group (200mg / kg / day dose group), 6 animals / group;

[0066] (3) Salvianolic acid B magnesium salt control group (salvianolic acid B magnesium salt mixed feed, no DMAB chemical induction): 1 group (200mg / kg / day dose group...

Embodiment 2

[0096] Experimental observation on the preventive effect of salvianolic acid B and its magnesium salt on liver cancer in rats

[0097] 1. Experimental materials

[0098] (1) Experimental animals: Wistar male rats, weighing about 90g;

[0099] (2) Chemical inducer of liver cancer: diethylnitrosamine (DENA);

[0100] (3) Experimental drugs: salvianolic acid B, magnesium salt of salvianolic acid B;

[0101] 2. Experimental grouping: The experimental animals are divided into 10 groups.

[0102] (1) Blank control group (normal diet, no DENA chemical induction): 1 group, 6 animals / group;

[0103] (2) Salvianolic acid B control group (salvianolic acid B mixed feed, no DENA chemical induction): 1 group (200mg / kg / day dose group), 6 animals / group;

[0104] (3) Salvianolic acid B magnesium salt control group (salvianolic acid B magnesium salt mixed feed, no DENA chemical induction): 1 group (200mg / kg / day dose group), 6 animals / group;

[0105] (4) DENA model control group (normal diet, with D...

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Abstract

An application of danshinolic acid in preparing the medicines in the form of tablet, oral liquid, injection, spray, or suppository for preventing tumor is disclosed.

Description

Technical field [0001] The present invention relates to the field of medicine, and more specifically to the application of salvianolic acid B and its pharmaceutical composition in the preparation of drugs for preventing tumor occurrence. Background technique [0002] Prostate cancer is one of the most common tumors in American men and the second leading cause of cancer death in American men. Approximately one in five American men will be diagnosed with prostate cancer in their lifetime. In 2004, it was estimated that there were approximately 230,000 new cases of prostate cancer and approximately 29,900 deaths from prostate cancer. On the other hand, the proportion of pathologically manifested prostate cancer among American men is even higher, about 34% among men aged 50 years and as high as 70% among men over 80 years old. More than 60% of newly diagnosed cases continue to progress pathologically, and their prognosis is not good. With the development of social economy, our countr...

Claims

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Application Information

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IPC IPC(8): A61K31/343A61K9/00A61P35/00
Inventor 谢天培戈萌季红光朱洪莉
Owner 上海天甲生物医药有限公司
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