A carbowax modified stealthy liposome nanosphere of hydroxycamtothecine and preparation method thereof

A technology of hydroxycamptothecin and stealth lipids, which is applied in liposome delivery, medical preparations with non-active ingredients, medical preparations containing active ingredients, etc., can solve the problem of increasing the toxicity of the reticuloendothelial system, hydroxycamptothecin Alkali leakage, affecting the stability of preparations and other issues, to achieve the effects of improving long-term stability, improving passive targeting, and simple and easy preparation methods

Active Publication Date: 2011-01-05
JIANKANGYUAN PHARMA GROUP
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  • Abstract
  • Description
  • Claims
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Problems solved by technology

However, as a drug delivery system, the emulsion has obvious targeting of the lymphatic system and the mononuclear phagocyte system (MPS), and has a better therapeutic effect on liver cancer. Toxicity of the reticuloendothelial system
In addition, due to the thin interfacial film of the emulsion, hydroxycamptothecin leakage is prone to occur during long-term storage, resulting in a decrease in encapsulation efficiency and drug precipitation, thereby affecting the stability of the formulation

Method used

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  • A carbowax modified stealthy liposome nanosphere of hydroxycamtothecine and preparation method thereof
  • A carbowax modified stealthy liposome nanosphere of hydroxycamtothecine and preparation method thereof
  • A carbowax modified stealthy liposome nanosphere of hydroxycamtothecine and preparation method thereof

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Abstract

The invention relate to polyethylene glycol modified hydroxycamptothecin stealth greasy nano balls for intravenous injection and its preparing process, which comprises treatment effective amount of hydroxycamptothecin, polyethylene glycol esters, oil for injection, phosphatides and pharmaceutically acceptable auxiliary material by the weight ratio of 0.01-0.2%, 1-10%, 5-25%, 0-10%, 0-10%, and balancing water. The invention also discloses the preparing prcesss including dissolving liposoluble materials into organic solvents, dissolving water-soluble auxiliary materials and addition agents intowater, mixing with organic phase, homogenizing or carrying out supersonic treatment.

Description

A polyethylene glycol-modified hydroxycamptothecin stealth lipid nanosphere and its preparation method technical field The invention belongs to the technical field of medicine, and relates to a polyethylene glycol-modified stealth lipid nanosphere and a preparation method thereof, in particular to a polyethylene glycol-modified hydroxycamptothecin stealth lipid nanosphere and a preparation method thereof. Background technique Hydroxycamptothecin is a trace alkaloid with the strongest anti-cancer effect among similar anti-tumor monomers extracted from camptotheca in the 1960s and 1970s, and it was used clinically in the 1980s. Hydroxycamptothecin is a cell cycle-specific drug that mainly acts on the DNA synthesis phase (S phase). Pharmacological studies have shown that its anticancer mechanism is to inhibit DNA topoisomerase I (TopoI), and it has certain curative effects on ascites-type liver cancer, head and neck tumors, gastric cancer, bladder cancer and leukemia. Hydrox...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K47/30A61K31/685A61K31/4745A61K9/19A61P35/00A61K9/127
Inventor 甘勇张馨欣甘莉
Owner JIANKANGYUAN PHARMA GROUP
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