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Novel use of xCT protein and its encoding gene

A technology for encoding genes and proteins, applied in genetic engineering, plant genetic improvement, peptide/protein components, etc.

Inactive Publication Date: 2006-12-27
INST OF GENETICS & DEVELOPMENTAL BIOLOGY CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

So far there is no effective drug that can stop the degeneration of neurons and reverse the disease

Method used

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  • Novel use of xCT protein and its encoding gene
  • Novel use of xCT protein and its encoding gene
  • Novel use of xCT protein and its encoding gene

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] Example 1. The Slc7a11 gene is a gene associated with neurodegenerative diseases

[0019] Subtle gray (sut / sut) mice (purchased from The Jackson Laboratory, USA) and C3H / HeSnJ mice (purchased from The Jackson Laboratory, USA) aged 9-14 weeks were subjected to SHIRPA ("a comprehensive phenotypic assessment system" , see URL: http: / / www.mgu.har.mrc.ac.uk / facilities / mutagenesis / mutabase / shirpa_summary.html) behavioral test, the results showed that 10 of the first batch of screening experiments (primary screen) In this experiment, there were differences between the two groups in the results, indicating that sut mice showed obvious central ataxia-like movement disorders ( figure 1 , C3H indicates C3H / HeSnJ mice). It is suggested that in sut mice (sut / sut), those motor nerve cells that are highly dependent on xCT uptake of cystine to resist oxidative stress damage show survival disorders due to xCT deficiency, causing neurodegeneration-like changes , resulting in correspond...

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Abstract

Disclosed is a novel use of xCT protein and gene coded by same in generation of nerve degeneration diseases. It is discovered for the first time that xCT protein and gene coded by same relates to generating mechanism of nerve degeneration diseases. A novel gene causing nerve degeneration diseases is discovered. Significance of the invention lies in that medicine improving expression quantity of Slc7a11 gene and xCT is screened by using Slc7a11 gene and xCT as targets, to improve expression quantity of Slc7a11 gene(normal gene) and xCT(normal protein), so to improve oxidation damage resistance ability of neurocyte, and as a result to prevent and slow down generation of nerve degeneration diseases. Animal models with the nerve degeneration disease of low expression quantity of Slc7a11 gene and xCT can be used to screen protein, nucleic acid, small organic molecule, and etc. which can improve expression quantity of Slc7a11 gene and xCT and use as candidate medicine.

Description

technical field [0001] The invention relates to the new application of xCT protein and its coding gene in neurodegenerative diseases. Background technique [0002] Mouse xCT is a transporter protein with 12 transmembrane domains composed of 502 amino acids encoded by the Slc7a11 gene. This gene was first published by Sato et al. a plasma membrane cystine / glutamate exchange transporter composed of two distinct proteins. J Biol Chem. 1999; 274: 11455-11458) was cloned and identified in 1999 (GenBank number: AB022345 or GI: 4689080; submission date: 13-JAN-1999). At the same time, it was found that the C158 residue of xCT combined with another subunit 4Fhc by forming a disulfide bond to form a protein dimer, which jointly constituted Xc - The amino acid (cystine / glutamic acid) transport system is dedicated to the transport of cystine from the extracellular to the intracellular, and at the same time transports glutamic acid out of the cell with a 1:1 exchange. [0003] Sut mic...

Claims

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Application Information

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IPC IPC(8): A61K38/17A61P25/28C12N15/12
Inventor 李巍乔海晅李岩柯尊记许执恒
Owner INST OF GENETICS & DEVELOPMENTAL BIOLOGY CHINESE ACAD OF SCI
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