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Method for preparing forsythia fruit effective part

A technology of effective parts and forsythia, which is applied in the field of extracting effective parts, can solve the problem of less forsythol and achieve the effects of shortening production time, improving efficiency and reducing cost

Active Publication Date: 2007-01-24
SHANDONG NEWTIME PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, through the patent search of the National Patent Office, it was found that there are very few patents on forsythol

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Get 5 kg of forsythia leaves, extract 3 times with 40 L of deionized water under hot reflux, the extraction time is 2, 2, and 1 hour respectively, the water extracts are combined, filtered, and concentrated under reduced pressure at 60 ° C to a relative density of 1.05 ( ), to obtain concentrated solution 10L; add ethanol to the concentrated solution until the ethanol concentration is 90%, precipitate overnight, filter, and the filtrate merges, reclaim the solvent under reduced pressure to a concentration of about 1.0g crude drug / ml, filter; Pore ​​adsorption resin, the amount of resin is 10kg, the flow rate is controlled to be 0.5~1.5BV / h, first eluted with 30L of water to remove impurities, and then eluted with 15L of 80% ethanol, the alcohol eluate is collected, concentrated under reduced pressure, vacuum dried and pulverized to obtain Forsythol 650g.

Embodiment 2

[0026] Get 5 kg of forsythia leaves, extract 3 times with 40 L of deionized water hot reflux, the extraction time is 2, 2, 1 hour respectively, the water extracts are combined, filtered, and concentrated under reduced pressure at 60 ° C to a relative density of 1.08 ( ), to obtain concentrated solution 8L; add ethanol to the concentrated solution until the ethanol concentration is 80%, precipitate overnight, filter, and the filtrate merges, reclaim the solvent under reduced pressure to a concentration of about 1.0g crude drug / ml, filter; Pore ​​adsorption resin, the amount of resin used is 15kg, the flow rate is controlled at 0.5~1.5BV / h, first eluted with 28L of water to remove impurities, and then eluted with 10L of 80% ethanol, the alcohol eluate is collected, concentrated under reduced pressure, vacuum dried and pulverized, Get forsythol 500g.

Embodiment 3

[0028] Get 5 kg of forsythia leaves, extract 3 times with 40 L of deionized water under hot reflux, the extraction time is 2, 2, and 1 hour respectively, the water extracts are combined, filtered, and concentrated under reduced pressure at 60 ° C to a relative density of 1.10 ( ), to obtain concentrated solution 7.5L; add ethanol to the concentrated solution until the ethanol concentration is 80%, precipitate overnight, filter, and the filtrates are combined, and the solvent is reclaimed under reduced pressure to a concentration of about 1.0g crude drug / ml, filtered; Macroporous adsorption resin, the amount of resin is 16kg, the flow rate is controlled at 0.5~1.5BV / h, first eluted with 25L of water to remove impurities, and then eluted with 12L of 80% ethanol, the alcohol eluate is collected, concentrated under reduced pressure, vacuum dried and pulverized , to get forsythol 450g.

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Abstract

The present invention discloses one new method of extracting forsythol as the effective component from forsythia, and the extracting method includes mainly water extraction, alcohol precipitation and macroporous resin adsorption. The extracting method has greatly shortened period and raised alcohol precipitated intermediate purity, and is suitable for industrial production.

Description

technical field [0001] The invention relates to a method for extracting effective parts, mainly forsythol, from forsythia. technical background [0002] Forsythia (Fructus Forsythiae) is a plant of the genus Forsythia in the family Oleaceae. In traditional Chinese prescriptions, the fruit of forsythia is often used as medicine, and it is used together with other heat-clearing and detoxifying drugs to clear away heat and detoxify, dissipate stagnation and reduce swelling. It is a commonly used traditional Chinese medicine recorded in the 2000 edition of "Chinese Pharmacopoeia". Among the forsythia plants, in addition to the fruit, there are also seeds that have the effect of clearing heat and detoxifying, and are often called "forsythia heart". Regarding the extraction of effective parts from Forsythia Fructus; in addition, there are some literatures reporting the antibacterial and antiviral activities of Forsythia Leaf Extract, such as "Study on Antibacterial Effect of Fors...

Claims

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Application Information

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IPC IPC(8): A61K36/634A61P31/04A61P31/12A61K131/00A61K127/00A61K133/00
Inventor 玄振玉黄孝春
Owner SHANDONG NEWTIME PHARMA
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