Dispersion tablets contg. Paris polyphylla total saponin

A technology of total saponins and dispersible tablets, which can be applied to medical preparations containing active ingredients, plant/algae/fungus/moss ingredients, plant raw materials, etc., and can solve the problem of single dosage form

Active Publication Date: 2007-01-31
YUNNAN BAIYAO GROUP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The dosage form is single, and patients have no choice

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0043] According to the calculation of preparing 1000 tablets, get 18.36 grams of Chonglou extract, 41.4 grams of microcrystalline cellulose, 47.1 grams of lactose, 47.1 grams of mannitol, 40.8 grams of cross-linked polyvinylpyrrolidone, 10.2 grams of oligomeric hypromellose, ten Sodium Dialkyl Sulfate 1.035 grams, made into 1000 tablets altogether. The raw materials are respectively passed through 100 mesh sieves, and 100ml of 95% medicinal alcohol binder containing 0.1%~3% of acesulfame is added to make soft materials, granulated with 50 mesh sieves, vacuum dried at 60°C for 3 hours, and granulated with 24 mesh sieves , add 1.035 grams of magnesium stearate and mix evenly, and press with an 8mm punch to obtain the dispersible tablet of the present invention.

Embodiment 2

[0045] According to the calculation of preparing 1000 tablets, take 18.36 grams of Chonglou extract, 41.4 grams of microcrystalline cellulose, 47.1 grams of lactose, 47.1 grams of mannitol, 40.8 grams of cross-linked carboxymethyl starch sodium, and 10.2 grams of oligomeric hypromellose , Sodium Lauryl Sulfate 1.035 grams, a total of 1000 tablets were made. The raw materials are respectively passed through 100 mesh sieves, and 100ml of 95% medicinal alcohol binder containing 0.1%~3% of acesulfame is added to make soft materials, granulated with 50 mesh sieves, vacuum dried at 60°C for 3 hours, and granulated with 24 mesh sieves , add 1.035 grams of magnesium stearate and mix evenly, press with 8mm punch to obtain the dispersible tablet of the present invention.

Embodiment 3

[0047]According to the calculation of preparing 1000 tablets, get 40.26 grams of Chonglou extract, 41.4 grams of microcrystalline cellulose, 36.15 grams of lactose, 36.15 grams of mannitol, 40.8 grams of cross-linked polyvinylpyrrolidone, 10.2 grams of oligomeric hypromellose, ten Sodium Dialkyl Sulfate 1.035 grams, made into 1000 tablets altogether. The raw materials are respectively passed through 100 mesh sieves, and 100ml of 95% medicinal alcohol binder containing 0.1%~3% of acesulfame is added to make soft materials, granulated with 50 mesh sieves, vacuum dried at 60°C for 3 hours, and granulated with 24 mesh sieves , add 1.035 grams of magnesium stearate and mix evenly, press with 8mm punch to obtain the dispersible tablet of the present invention.

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PUM

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Abstract

A dispersing tablet of Paris petiolata's saponin for treating metrorrhagia, metrostaxis, menorrhagia and poor uterine contraction is proportionally prepared from Paris petiolata's saponin, disintegrant, hydrophilic agent, adhesive and cosolvent.

Description

technical field [0001] The invention relates to a medicinal dosage form which can be rapidly disintegrated in contact with water, in particular to a dispersible tablet preparation which uses total saponins of pachyphyllum pachyrhiza as a single medicinal active ingredient. technical background [0002] Chonglou is a traditional precious Chinese medicine in my country. It is the rhizome of Paris petiolata Bak.ex Forb., a plant of Liliaceae, produced in Yunnan and Sichuan of China. Bitter in the mouth, slightly cold, slightly poisonous; Return to Liver Meridian. It has the functions of clearing away heat and detoxification, reducing swelling and relieving pain, cooling the liver and relieving convulsions. It is commonly used for boils and carbuncles, sore throat, poisonous snake bites, pain from tumbling, convulsions and convulsions. [0003] According to the 2005 edition of the Pharmacopoeia of the People's Republic of China, the total saponins of Chonglou are the active ing...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/896A61K9/20A61P15/00A61K125/00
Inventor 王真张文纲李巧凤万近福林怡
Owner YUNNAN BAIYAO GROUP
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