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Orthopaedics disease treating and preventing medicinal composition

An orthopedic disease and composition technology, which is applied in the field of pharmaceutical compositions composed of effective extracts of Epimedium and Rhizoma Drynariae can solve the problems of not finding the formation of massive osteoclasts and increasing the amount of ALP.

Inactive Publication Date: 2007-02-07
孙毅
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Osteocyte culture and bioassay showed that drynaria can significantly increase the amount of ALP in the cells, and at the same time the ACP and PGE2 in the medium increased significantly, making the formation of multinucleated osteoclasts more active, but no huge amount of osteoclasts was found, which has a significant effect on the formation of osteoclasts. Osteocytes may act by modulating osteoclast activity

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0067] Embodiment 1: Capsule prescription and technology

[0068] Prescription (based on 1000 capsules)

[0069] Epimedium Extract 20g

[0070] Drynaria Extract 20g

[0071] Starch 150ml

[0072] Micronized silica gel 10g

[0073] Makes 1000 capsules

[0074] Weigh 5 kg of Epimedium, add 10 times the amount of 70% ethanol to extract 3 times, each time for 1.5 hours, recover ethanol, concentrate in a water bath, and evaporate to dryness to obtain total flavonoids of Epimedium.

[0075] Drynaria drynariae was taken, dried at 60°C for 8 hours, crushed into a coarse powder (24 mesh), weighed 1kg, added 10L of 60% ethanol, refluxed for 1 hour, filtered, added 10L of 60% ethanol to the dregs, and refluxed for 1 hour. The filtrates were combined, the alcohol was distilled off under reduced pressure, filtered to obtain an aqueous solution, the pH value was adjusted to 9 with NaOH solution, and an equal amount of ethyl acetate was extracted to remove fat-melting impurities. Take ...

Embodiment 2

[0078] Embodiment 2: powder injection prescription and technology

[0079] Prescription (Based on 1000 bottles)

[0080] Epimedium Extract 10g

[0081] Drynaria Extract 5g

[0082] Mannitol 250g

[0083] Water for injection 10g

[0084] Makes 1000 bottles

[0085] The extraction method is the same as above. The molding process is as follows: take the prescription amount of Epimedium extract, Rhizoma Drynaria extract, mannitol, polyethylene glycol 400, and dissolve 80% of the prescription amount in water for injection; after initial filtration, fine filter with 0.2um microporous membrane; Make up the water for injection to the full amount; subpackage; lyophilize; pack.

example 3

[0086]Example 3: Injection prescription and process

[0087] Prescription (Based on 1000 bottles)

[0088] Epimedium Extract 10g

[0089] Drynaria Extract 5g

[0090] Add water for injection to 2000ml

[0091] Makes 1000 bottles

[0092] The extraction method is the same as above. The molding process is as follows: take the prescription amount of Epimedium extract, Rhizoma Drynaria extract, and dissolve 50% of the prescription amount in water for injection; use activated carbon for primary filtration and then fine filter with 0.2um microporous membrane; make up the injection water to the full amount; measure the content ; Dispensing; Sterilization; Light inspection; Packaging.

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PUM

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Abstract

The invention provides a Chinese medicinal composition for the effective prevention and treatment of orthopaedic diseases, which is prepared from barren wort extract and drynaria extract, and also comprises right amount of notoginseng extract or safflower extract.

Description

technical field [0001] The invention relates to a pharmaceutical composition for preventing and treating orthopedic diseases, in particular to a pharmaceutical composition composed of effective extracts of Epimedium and Rhizoma Drynariae. Background technique [0002] Orthopedic disease is a worldwide health problem that is attracting more and more attention. For example, at present, about 200 million people in the world suffer from osteoporosis, and its incidence rate has leapt to the seventh among common diseases and frequently-occurring diseases. The latest research shows that osteoporosis, which has always been considered as a disease unique to the elderly in our country, actually existed in childhood. With the aging of the population becoming more and more obvious, osteoporosis and its complications, a degenerative disease frequently occurring in middle-aged and elderly people, have become a social health problem, which has attracted the attention of geriatricians and ...

Claims

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Application Information

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IPC IPC(8): A61K36/296A61K9/00A61P19/08A61P19/02
Inventor 孙毅
Owner 孙毅
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